Table 6Principles for extrapolating from general depression population

Evidence from depression in the general populationEvidence from depression in adults with a chronic physical health problemDecision whether to extrapolateExample in the guideline
PositivePositiveYesPharmacological interventions, see Chapter 8; Physical activity and guided self-help, see Chapter 7
NegativePositiveNoCollaborative care, see Chapter 6
PositiveLimited/no robust evidenceJudgement of the GDG: If considered important then extrapolateDelivery of psychological interventions, see Chapter 7
PositiveNegative/contradictoryNoInterpersonal psychotherapy (IPT), see Chapter 7


Cover of Depression in Adults with a Chronic Physical Health Problem
Depression in Adults with a Chronic Physical Health Problem: Treatment and Management.
NICE Clinical Guidelines, No. 91.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2010.
Copyright © 2010, The British Psychological Society & The Royal College of Psychiatrists.

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