Table 11Summary of frequency of surveillance

Gupta et al. (2007)Jess et al. (2007)Karlen et al. (1998)Velayos et al. (2006)Overall quality
Study designRetrospective cohortRetrospective (assumed) cohort, with nested case–controlRetrospective cohort, with nested case–controlRetrospective case–controlVery low (retrospective and consistency could not be assessed)
Frequency of colonoscopyHR 1.7 (95% CI 0.9 to 3.0) for association of frequency of colonoscopy (1 or more per year) with any neoplasia
HR 3.9 (95% CI 1.3 to 11.4) for advanced neoplasia (univariate only)
Adjusted OR 5.3 (95% CI 1.4 to 20) for colorectal neoplasia if one or more colonoscopic surveillances during the disease course compared with no surveillanceRR 0.29 (95% CI 0.06 to 1.31) for risk of CRC mortality if colonoscopic surveillance ever compared with never.
RR 0.43 (95% CI 0.05 to 3.76) for risk of CRC mortality if one colonoscopic surveillance compared with never.
RR 0.22 (95% CI 0.03 to 1.74) for risk of CRC mortality if two or more colonoscopic surveillances compared with never.
Adjusted OR 0.4 (95% CI 0.2 to 0.7) for risk of CRC with one or two colonoscopies compared with none
Adjusted OR 0.3 (95% CI 0.1 to 0.8) for risk of CRC with two colonoscopies compared with none

HR: hazard ratio; CI: confidence interval; OR: odds ratio; RR: relative risk; CRC: colorectal cancer

Risk of CRC mortality: assessed as very low quality because of limitations in studies (retrospective and consistency could not be assessed).

Risk of CRC: assessed as very low quality because of limitations in study (retrospective and consistency could not be assessed).

Risk of advanced neoplasia: assessed as very low quality because of limitations in studies (retrospective, concerns over detection bias).

From: 2, How this guideline was developed

Cover of Colonoscopic Surveillance for Prevention of Colorectal Cancer in People with Ulcerative Colitis, Crohn's Disease or Adenomas
Colonoscopic Surveillance for Prevention of Colorectal Cancer in People with Ulcerative Colitis, Crohn's Disease or Adenomas.
NICE Clinical Guidelines, No. 118.
Centre for Clinical Practice at NICE (UK).
Copyright © 2011, National Institute for Health and Clinical Excellence.

All rights reserved. This material may be freely reproduced for educational and not-for-profit purposes. No reproduction by or for commercial organisations, or for commercial purposes, is allowed without the express written permission of NICE.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.