Clinical settingPatients with cerebral metastases and unknown primary tumour. Before PET patients received various combinations of: chest X-ray, mammography, bronchoscopy, US, abdominal/chest/pelvic CT and lab tests.
Participants and Country16 patients.
Study designRetrospective case series.
Target conditionIdentification of the primary tumour site. Reference standard was histology from biopsy or resection of the primary tumour or appearance of the lesion on CT / X-ray during follow up.
TestsFDG PET, General Electric Advance. 370 to 470 MBq.
Follow upNot reported
Study TypeII
PET imaging fieldWhole body
Biopsy of metastasisMetastasis was confirmed histologically in all cases. adenocarcinoma 14/16, 1 each of malignant melanoma and carcinoma.
NotesRelatively few had CT before PET, 2/16

From: Guideline chapter 2, Diagnosis

Cover of Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin
Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin.
NICE Clinical Guidelines, No. 104.
National Collaborating Centre for Cancer (UK).
Copyright © 2010, National Collaborating Centre for Cancer.

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