Clinical settingPatients with documented or suspected radiographic (CT or MRI) evidence of intracranial metastases, with unknown primary tumour. Only those with histological confirmation of metastases (22/31) had work-up for detection of the primary tumour.
Participants and Country31 patients, 9 with a history of malignancy.
Study designRetrospective case series. USA
Target conditionExtra cranial tumours were confirmed using clinical and CT/MRI follow up.
TestsFDG-PET, General Electric Advance. 10 mCi FDG
Follow upAt least 1 year
Study TypeII
PET imaging fieldWhole body
Biopsy of metastasis22/31 had histological confirmation of brain metastasis.
NotesThe main focus of the study is diagnosis of brain metastasis

From: Guideline chapter 2, Diagnosis

Cover of Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin
Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin.
NICE Clinical Guidelines, No. 104.
National Collaborating Centre for Cancer (UK).
Copyright © 2010, National Collaborating Centre for Cancer.

No part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licenses issued by the Copyright Licensing Agency in the UK. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.