Clinical settingPatients who presented with metastatic non-squamous carcinoma of unknown site
Participants and Country266 patients, 133 female, 65 mammograms
Study designThe paper is an expert review but includes previously unpublished data about mammography from: Nystrom JS, Weiner JM, Heffelfinger-Juttiner J, et al: Metastatic and histologic presentation of unknown primary cancer. Seminars in Oncology 4: 53–58, 1977
Target conditionIdentification of breast primary tumours. Reference standard for mammography was surgical biopsy for positive cases and autopsy for selected negative cases.
TestsMammography 65 tests were done: 3 were positive (suggesting a primary malignancy) - all of these were false positive. There were also three false negatives (three primary breast tumours not detected on mammogram).
Follow up
NotesIt is unclear what proportion of the patients had axillary metastases, however the Authors suggest that routine mammography is futile in patients without evidence of axillary metastases or masses within the breast.

From: Guideline chapter 2, Diagnosis

Cover of Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin
Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin.
NICE Clinical Guidelines, No. 104.
National Collaborating Centre for Cancer (UK).
Copyright © 2010, National Collaborating Centre for Cancer.

No part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licenses issued by the Copyright Licensing Agency in the UK. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.