Clinical settingPatients with brain metastases confirmed as metastatic carcinoma identified from the surgical pathology records of a single institution between 1990 and 2000.
Participants and Country75 patients. USA
Study designRetrospective case series
Target conditionPrimary tumour organ of origin. Reference standard was the diagnosis obtained from review of clinical and radiological records of each patient
TestsIHC markers: TTF-1
Follow upNot reported
Proportion with adenocarcinoma22/75, all others were excluded from this evidence review.
Primary or metastatic tumour?Metastases
Sample typeTissue from brain biopsy

From: Guideline chapter 2, Diagnosis

Cover of Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin
Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin.
NICE Clinical Guidelines, No. 104.
National Collaborating Centre for Cancer (UK).
Copyright © 2010, National Collaborating Centre for Cancer.

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