Table 4.2Diagnostic yield of initial and further diagnostic tests

StudyN patientsPrimaries identifiedPrimary tumour identified by initial tests*Treatable cancers identified by initial tests**Primary tumour identified by further tests*Treatable cancers identified by further tests**
Any presentation
Kirsten 198728658/286 (20%)--5829
Le Chevalier 1988302134/302 (44%)81not reported53not reported
Losa Gaspa 2002221175/221 (79%)13836377
Bone metastases
Alcalay 1995350109/350 (31%)8959205
Jacobsen 19972922/29 (76%)18641
Katigiri 19996460/64 (94%)4817121
Rougraff 19934036/40 (90%)34220
Simon 19864620/46 (43%)16541

Initial tests are defined in table 1


Treatable cancers defined as: breast, ovarian, germ cell, prostate, head/neck, thyroid,

From: Guideline chapter 2, Diagnosis

Cover of Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin
Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin.
NICE Clinical Guidelines, No. 104.
National Collaborating Centre for Cancer (UK).
Copyright © 2010, National Collaborating Centre for Cancer.

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