Table 22.1Palliative radiotherapy series of patients with brain metastases of unknown primary

StudyPopulationN (WBRT)WBRT detailsMedian OS (mths) WBRTN (WBRT + chemo)WBRT plus systemic therapy detailsMedian OS (mths) systemic therapyStatistical comparison
Bartelt 2003Patients with brain metastases of unknown primary32WBRT3.6None---
Debevec 1990Patients with brain metastases of unknown primary40WBRT4not reportednot reportednot reportednot reported
Hamann 1993Patients with brain metastases of unknown primary33Not reported5.1 **not reportednot reportednot reportednot reported
Khansur 1997Patients with brain metastases of unknown primary32WBRT4.52not reportednot reportednot reported
Kirschberger 1983Patients with brain metastases of unknown primary8WBRT2.2not reportednot reportednot reportednot reported
Kurtz 1981Patients with brain metastases of unknown primary (subgroup of a larger trial)12WBRT 30 or 50 Gy in 2 or 4 weeks respectively10.5not reportednot reportednot reportednot reported
Nguyen 1998Patients with brain metastases as the only manifestation of an unknown primary15WBRT<12none---
RadesPatients with brain metastases of unknown primary101WBRT plus corticosteroids4not reportednot reportednot reportednot reported
Shaw 2007Patients with brain metastases of unknown primary21Cranial radiotherapy alone or supportive care2.0none---
*

from metastasis to death.

**

combined results from 33 patients with CUP and 46 with known primary. Abbreviations: OS, overall survival; WBRT, whole brain radiotherapy;

From: Guideline chapter 4, Specific Presentations

Cover of Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin
Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin.
NICE Clinical Guidelines, No. 104.
National Collaborating Centre for Cancer (UK).
Copyright © 2010, National Collaborating Centre for Cancer.

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