NATIONAL COLLABORATING CENTRE FOR CANCER
Cancer of Unknown Primary Clinical GuidelineLiterature search summary
Question title: For patients with malignancy of undefined primary origin, is it beneficial for investigations to be undertaken to end uncertainty when there is little likelihood of clinical benefit?
Question no: 7
49. Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
MedlineAll120613/05/09
PremedlineAll3013/05/09
EmbaseAll189420/05/09
Cochrane LibraryAll16013/05/09
CinahlAll64426/05/09
PsychinfoAll6013/05/09
Web of Science (SCI & SSCI & ISI Proceedings))All249226/05/09
BIOSISAll243026/05/09
Total References retrieved (after de-duplication): 14
(Also see update searches below)
Total References retrieved after Update Searching: 2
Medline search strategy (This search strategy is adapted to each database.)
  1. Neoplasms, Unknown Primary/
  2. ((Unknown primar$ or unknown origin$1) and (cancer$ or neoplas$ or tumo$ or carcinoma$ or adeno$ or metasta$ or micrometasta$ or malignan$ or lymphoma$ or sarcoma$ or melanoma$)).tw.
  3. (Occult adj5 (cancer$ or neoplas$ or tumo$ or carcinoma$ or adeno$ or metasta$ or micrometasta$ or malignan$ or lymphoma$ or sarcoma$ or melanoma$)).tw.
  4. ((Undetermined primar$ or undetermind origin$1) adj5 (cancer$ or neoplas$ or tumo$ or carcinoma$ or adeno$ or metasta$ or micrometasta$ or malignan$ or lymphoma$ or sarcoma$ or melanoma$)).tw.
  5. ((Unidentifi$ primar$ or unidentifi$ origin$1) adj5 (cancer$ or neoplas$ or tumo$ or carcinoma$ or adeno$ or metasta$ or micrometasta$ or malignan$ or lymphoma$ or sarcoma$ or melanoma$)).tw.
  6. ((Undefined primar$ or undefined origin$1) adj5 (cancer$ or neoplas$ or tumo$ or carcinoma$ or adeno$ or metasta$ or micrometasta$ or malignan$ or lymphoma$ or sarcoma$ or melanoma$)).tw.
  7. or/1–6
  8. exp Adaptation, Psychological/
  9. Stress, Psychological/
  10. exp Emotions/
  11. uncertainty/
  12. (depression or anxiety or anger or hopelessness or helplessness or stress or self-esteem or coping or distress).tw.
  13. (psycholog$ adj support$).tw.
  14. (social adj support$).tw.
  15. (patient$ adj support$).tw.
  16. or/8–16
  17. Physician-Patient Relations/
  18. exp Professional-Family Relations/
  19. Truth Disclosure/
  20. ((doctor$ or clinician$ or professional$ or physician$ or consultant$ or oncologist$) adj confidence).tw.
  21. counsel$.tw.
  22. or/18–22
  23. Attitude to Death/
  24. 17 or 23 or 24
  25. 25 and 7
50. Health Economics Literature search details - NOT REQUIRED
(SIGN Health Economics filter added to above search)
[Indicate if SCHARR Quality of Life filter added to above search]
Database nameNo of references foundFinish date of search
Medline
Premedline
Embase
Cochrane Library (except NHSEED)
NHSEED
Cinahl
Psycinfo
EconLit
Web of Science (SCI & SSC & ISI ProceedingsI)
51. Any further comments:
Sifting Criteria:
52. Update Searches
New references added:
DateDatabaseNo. of new refs
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2008–965121/09/09
Premedline2008–95021/09/09
Embase2008–972121/09/09
Cochrane Library2008–99021/09/09
Cinahl2008–968206/10/09
Psychinfo2008–95021/09/09
Web of Science (SCI & SSCI & ISI Proceedings))2008–992021/09/09
HMIC2008–92021/09/09

From: Appendix A, Search Strategies

Cover of Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin
Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin.
NICE Clinical Guidelines, No. 104.
National Collaborating Centre for Cancer (UK).
Copyright © 2010, National Collaborating Centre for Cancer.

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