NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: What is the effectiveness of Radiotherapy at treating spinal pain and/or preventing spinal collapse and/or spinal cord compression?
Question no: 2c
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 2006216518224/01/07
Premedline1950 – 2006431129/01/07
Embase1980 – 2006413210025/01/07
Cochrane Library1800 – 20068663324/01/07
Cinahl1982 – 200681429/01/07
BNI1994 – 20061129/01/07
Psychinfo1967– 20060029/01/07
SIGLE1980 – 20050029/01/07
Web of Science (SCI & SSCI)1970 – 2006193911529/01/07
ISI Proceedings1990 – 20062181129/01/07
Biomed Central1997 – 200618029/01/07
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2006 – 04/20085053418/04/08
Premedline2006 – 04/200836718/04/08
Embase2006 – 04/20085741218/04/08
Cochrane Library2006 – 04/200844218/04/08
Cinahl2006 – 04/200828018/04/08
BNI2006 – 04/20080018/04/08
Psychinfo2006 – 04/20080018/04/08
Web of Science (SCI & SSCI)2006 – 04/20082733218/04/08
ISI Proceedings2006 – 04/200835718/04/08
Biomed Central2006 – 04/200815018/04/08
Total References retrieved (after de-duplication): 332 (update search: 59)
Medline search strategy (This search strategy is adapted to each database.)

Spinal Cord Compression AND Radiotherapy
(RCT, SR and OS filter applied)
  1. exp Spine/
  2. exp Spinal Neoplasms/
  3. osseous metasta$.tw.
  4. (spin$ adj3 metasta$).tw.
  5. (vertebra$ adj3 (cancer$ or carcinoma$ or malignan$ or tumo?r$ or neoplas$ or intraepithelial$ or adeno$)).tw.
  6. vertebra$ metastas$.tw.
  7. spin$ collaps$.tw.
  8. spin$ instabil$.tw.
  9. spin$ pain.tw.
  10. or/1–12
  11. radiotherap$.tw.
  12. (radiat$ adj2 therap$).tw.
  13. irradiat$.tw.
  14. (interstitial adj (irradiation or radiation)).tw.
  15. (radiat$ adj2 treatment$).tw.
  16. (three dimensional adj2 radiotherap$).tw.
  17. 3D radiotherap$.tw.
  18. 3DCRT.tw.
  19. external beam radiotherap$.tw.
  20. systemic radiotherap$.tw.
  21. or/14–24
Health Economics Literature search details

SIGN Health Economics and SCHARR Quality of Life filter added to search.
Database nameNo of references foundFinish date of search
Medline15026/04/07
Premedline126/04/07
Embase48226/04/07
Cochrane Library (except NHSEED)502/05/07
NHSEED602/05/07
Cinahl3826/04/07
Psycinfo026/04/07
BNI026/04/07
EconLit026/04/07
Web of Science (SCI & SSCI)12426/04/07
ISI Proceedings1126/04/07
SIGLE026/04/07
UPDATE SEARCH
Database nameNo of references foundFinish date of search
Medline118/04/08
Premedline018/04/08
Embase218/04/08
Cochrane Library (except NHSEED)018/04/08
NHSEED218/04/08
Cinahl118/04/08
Psycinfo018/04/08
BNI018/04/08
EconLit018/04/08
Web of Science (SCI & SSCI)218/04/08
ISI Proceedings018/04/08
Any further comments:
The update search was performed to include the years 2007 – 18 April 2008 only.
The Health Economics update search was performed to include the years 2007 – 18 April 2008 only.

From: Appendix A, Literature Searches

Cover of Metastatic Spinal Cord Compression
Metastatic Spinal Cord Compression: Diagnosis and Management of Patients at Risk of or with Metastatic Spinal Cord Compression.
NICE Clinical Guidelines, No. 75.
National Collaborating Centre for Cancer (UK).
Copyright © 2008, National Collaborating Centre for Cancer.

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