Table 26Summary of studies on growth retardation

NDesignPopulationDurationResultsQuality rating
Head-to-head comparisons of ICS compared with ICS
De Benedictis et al. 200131343RCTPre-pubertal children with asthma1 yearGreater growth velocity in FP than in BDP groupFair
Ferguson et al, 199944333RCTChildren with asthma20 weeksGreater growth velocity in FP than in BUD groupFair
Kannisto et al. 200024975RCTChildren with asthma1 yearGreater growth velocity in FP than in BUD groupFair
von Berg et al. 200762621RCTChildren with asthma12 weeksGreater increase in growth in CIC than in BUD groupFair
General evidence from ICS-treated subjects compared with non-ICS treated controls
Sharek et al. 1999246273Meta-analysisChildren with asthmaMore than 3 monthsReduction in growth for BDP compared to placeboGood
Sharek et al. 2000247855Meta-analysisChildren with asthma7 months to 54 weeksReduction in growth of 0.43 and 1.51 cm/year for BDP and FP, respectively, vs. placeboGood
Childhood Asthma Management Program Research Group, 2000255, 2561041RCTChildren with asthma4.3 yearsReduction in growth (1.1 cm) for BUD- treated childrenGood
Allen et al. 1998254268RCTChildren with asthma1 yearNo differences in height and growth velocity between FP and placeboFair
Becker et al. 2006124360RCTChildren with asthma56 weeksReduction in growth for BDP-treated childrenFair

Abbreviations: BDP = beclomethasone dipropionate; BUD = Budesonide; CIC = Ciclesonide; FP = Fluticasone Propionate; ICS = Inhaled Corticosteroids; RCT= randomized controlled trial; SR=systematic review.

From: Results

Cover of Drug Class Review: Controller Medications for Asthma
Drug Class Review: Controller Medications for Asthma: Final Update 1 Report [Internet].
Jonas DE, Wines RCM, DelMonte M, et al.
Portland (OR): Oregon Health & Science University; 2011 Apr.
Copyright © 2011 by Oregon Health & Science University.

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