Table 2. Surveillance Testing During and After Treatment for Medulloblastoma, CNS Primitive Neuroectodermal Tumor, Medulloepithelioma, Ependymoblastoma, and Pineoblastoma

Surveillance Period Frequency of Visits During Surveillance PeriodTesting
First 3 years after diagnosis Every 3 months Physical exam
Imaging of the brain every 3 months for the first 3 years, then every 6 months for the ensuing 2 years, and then as per preference of the treating physician or per protocol; MRI of the spine every 3 months for the first 2 years, then every 6 months for 1 year, and then as per preference of the treating physician or per protocol.a
Endocrinology evaluation once a year
Neuropsychologic testing every 1–2 years
3–5 years after diagnosis Every 6 months Physical exam
Imaging of the brain and spine once a year
Endocrinology evaluation once a year
Neuropsychologic testing every 1–2 years
More than 5 years after diagnosis Once a year Physical exam
Imaging of the brain once a year
Endocrinology evaluation once a year
Neuropsychologic testing every 1–2 years (optional)

CNS = central nervous system; MRI = magnetic resonance imaging.

aFor pineoblastoma, continue spinal evaluations every 6 months until 5 years from diagnosis. Although these suggestions are based on a small sample size, there is evidence to continue surveillance testing of the spine until 5 years after diagnosis.[80]

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