Table 2. The International Staging System (R-ISS) for Multiple Myeloma

StageCriteriaMedian Survival (mo)
IBeta-2-microglobulin <3.5 mg/L and albumin ≥3.5 g/dLNot reached
IINot R-ISS I or III83
IIIBeta-2-microglobulin ≥5.5 mg/L and either high LDH or high-risk chromosomal abnormalities by I-FISH (defined as presence of del (17p) and/or translocation t(4;14) and/or translocation t(14;16))43

I-FISH = interphase fluorescence in situ hybridization; LDH = lactate dehydrogenase; mo = month; R-ISS = Revised International Staging System

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