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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].

A meta-analysis of the therapeutic effects of tumor necrosis factor-alpha blockers on ulcerative colitis

Review published: 2011.

Bibliographic details: Huang X, Lv B, Jin HF, Zhang S.  A meta-analysis of the therapeutic effects of tumor necrosis factor-alpha blockers on ulcerative colitis. European Journal of Clinical Pharmacology 2011; 67(8): 759-766. [PubMed: 21691804]

Abstract

PURPOSE: To evaluate the therapeutic effects of TNF-α blockers on ulcerative colitis (UC) and their safety.

METHODS: Randomized controlled trials (RCTs) of TNF-α blockers for treatment of UC were retrieved from databases. Heterogeneity test was performed on all data to select effects models. Finally, sensitivity analysis was carried out, and a funnel plot was drawn to evaluate publication bias.

RESULTS: A total of nine RCTs conformed to the inclusion criteria. Of 1,226 patients with UC, 806 were given a TNF-α blocker, and 420 were given placebo or other drugs as control. Infliximab was used in eight papers and adalimumab in one paper. Placebo was used in seven papers and hormones in two papers. Short-term response, short-term relief, long-term response, and long-term relief were better in the TNF-α blocker group than in the control group (P < 0.05). TNF-α blockers decreased the colectomy rate (P < 0.05). There were no significant differences in mucosal healing and quality of life between the two groups (P > 0.05). The rates of adverse reactions were similar in the two groups (P > 0.05), but the rate of severe adverse reactions was significantly lower in the TNF-α blocker group than in the control group (P < 0.05). The funnel plot of each parameter was symmetrical with the lower part broader than the upper.

CONCLUSIONS: TNF-α blockers have better therapeutic effects on moderate or severe UC, which shows little response to conventional therapy. TNF-α blockers can induce short-term response, maintain long-term clinical response and clinical relief, and decrease the colectomy rate and the severe adverse reaction rate, but they fail to improve quality of life and mucosal healing.

CRD has determined that this article meets the DARE scientific quality criteria for a systematic review.

Copyright © 2014 University of York.

PMID: 21691804

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