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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].

A meta-analysis of the safety of simultaneous versus staged resection for synchronous liver metastasis from colorectal cancer

Review published: 2010.

Bibliographic details: Chen GQ, Li J, Ding KF.  A meta-analysis of the safety of simultaneous versus staged resection for synchronous liver metastasis from colorectal cancer. Chinese Journal of Gastrointestinal Surgery 2010; 13(5): 337-341. [PubMed: 20499300]

Abstract

OBJECTIVE: To evaluate the safety of simultaneous and staged resection for synchronous liver metastasis from colorectal cancer.

METHODS: PubMed/Medline, ISI Web of Knowledge, Springer link, ebscohost, Elsevier Wiley Interscience, Google Scholar were searched for case-control studies concerning simultaneous versus staged resection of synchronous liver metastasis from colorectal cancer between January 1989 and March 2009. A meta-analysis was performed to analyze the morbidity and perioperative mortality.

RESULTS: Seven case-control studies, with a total of 1390 patients of liver metastasis from colorectal cancer undergone curative hepatic resection, were reviewed. There were 495 simultaneous and 895 staged resections. Perioperative mortality was 1.1% in the staged resection group and 2.4% in the the simultaneous group, the difference was statistically significant[Peto OR 3.39, 95% CI 1.29-8.93, P=0.01]. No significant difference was found in morbidity between two groups[OR(random)0.88, 95% CI 0.51-1.51, P=0.64].

CONCLUSION: Selective staged resection is safe for synchronous liver metastasis from colorectal cancer.

CRD has determined that this article meets the DARE scientific quality criteria for a systematic review.

Copyright © 2014 University of York.

PMID: 20499300

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