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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].
Show detailsBibliographic details: Cavallazzi R, Cavallazzi A C. The effect of corticosteroids on the prevention of fat embolism syndrome after long bone fracture of the lower limbs: a systematic review and meta-analysis. [O efeito do corticosteroide na prevencao da sindrome da embolia gordurosa apos fratura de osso longo dos membros inferiores: revisao sistematica com meta-analise.] Jornal Brasileiro de Pneumologia 2008; 34(1): 34-41. [PubMed: 18278374]
Abstract
OBJECTIVE: To analyze the available evidence regarding the effect that corticosteroids have on the prevention of fat embolism syndrome after long bone fracture of the lower limbs or pelvic fracture.
METHODS: In March of 2007, we performed a search of various electronic databases, including Medline, the Excerpta Medica database, the Cochrane Library, the Latin American and Caribbean Health Sciences Literature database and the Scientific Electronic Library Online. We selected randomized controlled trials that compared the effect of corticosteroids with that of placebo (or standard care) on the prevention of fat embolism syndrome after long bone fracture of the lower limbs or pelvic fracture. References from the studies included were also reviewed.
RESULTS: Six studies were included. The pooled relative risk for developing fat embolism syndrome was 0.16 (95% CI: 0.08-0.35) in the corticosteroid group as compared with the control group. The pooled relative risk for developing hypoxemia was 0.34 (95% CI: 0.19-0.59) in the corticosteroid group as compared with the control group.
CONCLUSION: The analysis of evidence showed that corticosteroids decrease the risk of developing fat embolism syndrome and hypoxemia after long bone fracture of the lower limbs.
- Review The use of corticosteroid for the prophylaxis of fat embolism syndrome in patients with long bone fracture.[Rev Col Bras Cir. 2013]Review The use of corticosteroid for the prophylaxis of fat embolism syndrome in patients with long bone fracture.Silva DF, Carmona CV, Calderan TR, Fraga GP, Nascimento B, Rizoli S. Rev Col Bras Cir. 2013 Sep-Oct; 40(5):423-6.
- Review Do corticosteroids reduce the risk of fat embolism syndrome in patients with long-bone fractures? A meta-analysis.[Can J Surg. 2009]Review Do corticosteroids reduce the risk of fat embolism syndrome in patients with long-bone fractures? A meta-analysis.Bederman SS, Bhandari M, McKee MD, Schemitsch EH. Can J Surg. 2009 Oct; 52(5):386-93.
- 'Low-dose' corticosteroid prophylaxis against fat embolism.[J Trauma. 1987]'Low-dose' corticosteroid prophylaxis against fat embolism.Kallenbach J, Lewis M, Zaltzman M, Feldman C, Orford A, Zwi S. J Trauma. 1987 Oct; 27(10):1173-6.
- Prevention of posttraumatic hypoxaemia in isolated lower limb long bone fractures with a minimal prophylactic dose of corticosteroids.[Injury. 2004]Prevention of posttraumatic hypoxaemia in isolated lower limb long bone fractures with a minimal prophylactic dose of corticosteroids.Babalis GA, Yiannakopoulos CK, Karliaftis K, Antonogiannakis E. Injury. 2004 Mar; 35(3):309-17.
- Fat embolism prophylaxis with corticosteroids. A prospective study in high-risk patients.[Ann Intern Med. 1983]Fat embolism prophylaxis with corticosteroids. A prospective study in high-risk patients.Schonfeld SA, Ploysongsang Y, DiLisio R, Crissman JD, Miller E, Hammerschmidt DE, Jacob HS. Ann Intern Med. 1983 Oct; 99(4):438-43.
- The effect of corticosteroids on the prevention of fat embolism syndrome after l...The effect of corticosteroids on the prevention of fat embolism syndrome after long bone fracture of the lower limbs: a systematic review and meta-analysis - Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews
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