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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].
Show detailsBibliographic details: Goh Y I, Bollano E, Einarson T R, Koren G. Prenatal multivitamin supplementation and rates of pediatric cancers: a meta-analysis. Clinical Pharmacology and Therapeutics 2007; 81(5): 685-691. [PubMed: 17314929]
Abstract
Prenatal supplementation of folic acid has been shown to decrease the risk of several congenital malformations. Several studies have recently suggested a potential protective effect of folic acid on certain pediatric cancers. The protective role of prenatal multivitamins has not been elucidated. We conducted a systematic review and meta-analysis to assess the potential protective effect of prenatal multivitamins on several pediatric cancers. Medline, PubMed, EMBASE, Toxline, Healthstar, and Cochrane databases were searched for studies published in all languages from 1960 to July 2005 on multivitamin supplementation and pediatric cancers. References from all articles collected were reviewed for additional articles. Two blinded independent reviewers assessed the articles for inclusion and exclusion. Rates of cancers in women supplemented with multivitamins were compared with unsupplemented women using a random effects model. Sixty-one articles were identified in the initial search, of which, seven articles met the inclusion criteria. There was an apparent protective effect for leukemia (odds ratio (OR)=0.61, 95% confidence interval (CI)=0.50-0.74), pediatric brain tumors (OR=0.73, 95% CI=0.60-0.88) and neuroblastoma (OR=0.53, 95% CI=0.42-0.68). In conclusion, maternal ingestion of prenatal multivitamins is associated with a decreased risk for pediatric brain tumors, neuroblastoma, and leukemia. Presently, it is not known which constituent(s) among the multivitamins confer this protective effect.
- Review Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis.[J Obstet Gynaecol Can. 2006]Review Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis.Ingrid Goh Y, Bollano E, Einarson TR, Koren G. J Obstet Gynaecol Can. 2006 Aug; 28(8):680-689.
- Review Prenatal supplementation with multivitamins and the incidence of pediatric cancers: clinical and methodological considerations.[Pediatr Blood Cancer. 2008]Review Prenatal supplementation with multivitamins and the incidence of pediatric cancers: clinical and methodological considerations.Goh YI, Koren G. Pediatr Blood Cancer. 2008 Feb; 50(2 Suppl):487-9; discussion 498.
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- Prenatal vitamin supplementation and pediatric brain tumors: huge international variation in use and possible reduction in risk.[Childs Nerv Syst. 1998]Prenatal vitamin supplementation and pediatric brain tumors: huge international variation in use and possible reduction in risk.Preston-Martin S, Pogoda JM, Mueller BA, Lubin F, Modan B, Holly EA, Filippini G, Cordier S, Peris-Bonet R, Choi W, et al. Childs Nerv Syst. 1998 Oct; 14(10):551-7.
- Results from an international case-control study of childhood brain tumors: the role of prenatal vitamin supplementation.[Environ Health Perspect. 1998]Results from an international case-control study of childhood brain tumors: the role of prenatal vitamin supplementation.Preston-Martin S, Pogoda JM, Mueller BA, Lubin F, Modan B, Holly EA, Filippini G, Cordier S, Peris-Bonet R, Choi W, et al. Environ Health Perspect. 1998 Jun; 106 Suppl 3(Suppl 3):887-92.
- Prenatal multivitamin supplementation and rates of pediatric cancers: a meta-ana...Prenatal multivitamin supplementation and rates of pediatric cancers: a meta-analysis - Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews
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