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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].

What is the risk of sham surgery in Parkinson disease clinical trials: a review of published reports

Review published: 2005.

Bibliographic details: Frank S, Kieburtz K, Holloway R, Kim S Y.  What is the risk of sham surgery in Parkinson disease clinical trials: a review of published reports. Neurology 2005; 65(7): 1101-1103. [PubMed: 16033990]

Abstract

Placebo, or sham surgery, as a control condition in surgical clinical trials in Parkinson disease (PD) remains controversial. The authors reviewed the adverse effects reported in double blind, placebo surgery controlled trials for PD. Placebo surgeries were generally safe and well tolerated but the number of subjects receiving the procedure was small. Harm occurred more frequently in subjects randomized to the experimental intervention.

CRD has determined that this article meets the DARE scientific quality criteria for a systematic review.

Copyright © 2014 University of York.

PMID: 16033990

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