Table 105Summary of findings on nonpharmacologic treatment of adult treatment-resistant depression (TRD) with strength of evidence for Tier 1 (TRD) for KQ 5. efficacy and harms for selected populations

ComparisonOutcomeNumber of SubjectsStrength of Evidence*Findings
rTMS vs. shamChanges in depressive severity34Low1 fair trial: rTMS produced better outcome than sham in young adult population (ages 18–37).
rTMS vs. shamChanges in depressive severity20Low1 fair trial: rTMS produced better outcome than sham in older adults with post-stroke depression.
rTMS vs. shamResponse34Low1 fair trial: rTMS produces better response rates than sham in young adult population (ages 18–37).
rTMS vs. shamResponse20Low1 fair trial: no difference between rTMS and sham for older adults with post-stroke depression.
rTMS vs. shamRemission20Low1 fair trial: no difference between rTMS and sham in older adults with post-stroke depression.

rTMS = repetitive transcranial magnetic stimulation; vs. = versus

*

Strength of evidence is based on guidance provided in the AHRQ Methods Guide for Comparative Effectiveness Reviews; see text.

Good and fair designations relate to quality ratings for each study.

From: Discussion

Cover of Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults
Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults [Internet].
Comparative Effectiveness Reviews, No. 33.
Gaynes BN, Lux LJ, Lloyd SW, et al.

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