Table 65Withdrawals due to adverse events of rTMS versus sham: Tier 1, MDD and ≤ 20 percent bipolar disorder

Author, Year
Design
Duration
Quality
Intervention and Sample Size
Study Details
Discontinuations During Treatment
Fitzgerald et al., 200618
RCT
6 weeks
Fair
High plus low rTMS (n = 25)
High-frequency rTMS up to 30 sessions plus low-frequency rTMS up to 30 sessions
Sham (n = 25)
Due to AEs: 0
Fitzgerald et al., 200380
RCT
Phase I: 2 weeks
Fair
High rTMS (n = 20)
High frequency, 10 sessions
Low rTMS (n = 20)
Low frequency, 10 sessions
Sham (n = 20)
Due to AEs: 0
Pallanti et al., 2010{#2551}
RCT
3 weeks
Fair
Low plus High rTMS (n = 20)
Low then high frequency, 15 sessions
rTMS (n = 20)
Low frequency, 15 sessions
Sham (n = 20)
Due to AEs, n (%):
Low plus high rTMS: 0 (0)
Low rTMS: 0 (0)
Sham: 0 (0)
P = NR
Su et al., 200581
RCT
2 weeks
Fair
20 Hz rTMS (n = 11)
High frequency (20 Hz), 10 sessions
5 Hz rTMS (n = 11)
High frequency (5 Hz),10 sessions
Sham (n = 11)
Due to AEs, %:
All rTMS: 9.1
20 Hz rTMS: 0
5 Hz rTMS: 17
Sham: 0
P = NR

AE = adverse event; Hz = hertz; n = number; RCT = randomized controlled trial, rTMS = repetitive transcranial magnetic stimulation

From: Results

Cover of Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults
Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults [Internet].
Comparative Effectiveness Reviews, No. 33.
Gaynes BN, Lux LJ, Lloyd SW, et al.

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