Is IPT (3-year maintenance treatment) + antidepressants effective compared with medication clinic + antidepressants?

Quality assessmentSummary of findingsImportance
No. of patientsEffectQuality
No. of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsIPT (3-year maintenance treatment) + ADMedication clinic + ADRelative (95% CI)Absolute
Relapse
2randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessserious1none15/50 (30%)27/56 (48.2%)RR 0.62 (0.38 to 1.02)183 fewer per 1000 (from 299 fewer to 10 more)⊕⊕⊕○
MODERATE
CRITICAL
0%0 fewer per 1000 (from 0 fewer to 0 more)
1

Inconclusive effect size

From: APPENDIX 16, CLINICAL EVIDENCE PROFILES

Cover of Depression
Depression: The Treatment and Management of Depression in Adults (Updated Edition).
NICE Clinical Guidelines, No. 90.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2010.
Copyright © The British Psychological Society & The Royal College of Psychiatrists, 2010.

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