Is physical activity (supervised) effective compared with no physical activity control?

Quality assessmentSummary of findingsImportance
No. of patientsEffectQuality
No. of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsPhysical activity (supervised)No physical activity controlRelative (95% CI)Absolute
Clinician-rated depression scores (Better indicated by lower values)
5randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessno serious imprecisionnone110103-SMD 1.26 lower (2.12 to 0.37 lower)⊕⊕⊕⊕
HIGH
CRITICAL
Clinician-rated depression scores at 24 weeks (Better indicated by lower values)
1randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessvery serious1none1211-SMD 0.15 higher (0.67 lower to 0.97 higher)⊕⊕○○
LOW
CRITICAL
Clinician-rated depression scores at 34–36 weeks (Better indicated by lower values)
1randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessno serious imprecisionnone5657-SMD 0.38 lower (0.75 to 0.01 lower)⊕⊕⊕⊕
HIGH
CRITICAL
Self-rated depression scores (Better indicated by lower values)
7randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessno serious imprecisionnone214190-SMD 0.74 lower (1.19 to 0.29 lower)⊕⊕⊕⊕
HIGH
CRITICAL
Self-rated depression scores at 4 weeks (Better indicated by lower values)
1randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessserious2none4834-SMD 1.58 lower (2.09 to 1.08 lower)⊕⊕⊕○
MODERATE
CRITICAL
Self-rated depression scores at 8 weeks (Better indicated by lower values)
1randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessserious2none4834-SMD 1.06 lower (1.53 to 0.59 lower)⊕⊕⊕○
MODERATE
CRITICAL
Self-rated depression scores at 34 weeks (Better indicated by lower values)
1randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessvery serious1none4343-SMD 0.24 lower (0.67 lower to 0.18 higher)⊕⊕○○
LOW
CRITICAL
Leaving treatment early
3randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessserious3none17/104 (16.3%)0%RR 1.47 (0.72 to 3.01)0 more per 1000 (from 0 fewer to 0 more)⊕⊕⊕○
MODERATE
CRITICAL
1

Single study and inconclusive effect size

2

Single study

3

Inconclusive effect size

From: APPENDIX 16, CLINICAL EVIDENCE PROFILES

Cover of Depression
Depression: The Treatment and Management of Depression in Adults (Updated Edition).
NICE Clinical Guidelines, No. 90.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2010.
Copyright © The British Psychological Society & The Royal College of Psychiatrists, 2010.

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