Is collaborative care effective compared with standard care? (Acceptability and adherence data)

Quality assessmentSummary of findingsImportance
No. of patientsEffectQuality
No. of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsCollaborative careControlRelative (95% CI)Absolute
Attrition - Leaving study early for any reason (including lost to follow-up)
17randomised trialsno serious limitationsserious1no serious indirectnessno serious imprecisionnone472/3089 (15.3%)412/2253 (18.3%)RR 0.95 (0.78 to 1.16)1 fewer per 100 (from 4 fewer to 3 more)⊕⊕⊕○
MODERATE
18.3%1 fewer per 100 (from 4 fewer to 3 more)
Adherence - Non-adherence to medication
4randomised trialsno serious limitationsserious1no serious indirectnessno serious imprecisionnone151/491 (30.8%)240/465 (51.6%)RR 0.58 (0.44 to 0.75)22 fewer per 100 (from 13 fewer to 29 fewer)⊕⊕⊕○
MODERATE
51.3%22 fewer per 100 (from 13 fewer to 29 fewer)
1

Significant heterogeneity - random effects model used

From: APPENDIX 16, CLINICAL EVIDENCE PROFILES

Cover of Depression
Depression: The Treatment and Management of Depression in Adults (Updated Edition).
NICE Clinical Guidelines, No. 90.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2010.
Copyright © The British Psychological Society & The Royal College of Psychiatrists, 2010.

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