Is short-term psychodynamic psychotherapy + antidepressants effective compared with supportive therapy + antidepressants?

Quality assessmentSummary of findingsImportance
No. of patientsEffectQuality
No. of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsShort-term psychodynamic psychotherapy + ADSupportive therapy + ADRelative (95% CI)Absolute
Leaving study early
1randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessvery serious1none14/47 (29.8%)10/48 (20.8%)RR 1.43 (0.71 to 2.89)90 more per 1000 (from 60 fewer to 394 more)⊕⊕○○
LOW
CRITICAL
0%0 more per 1000 (from 0 fewer to 0 more)
Non-remitters
1randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessvery serious1none31/47 (66%)29/48 (60.4%)RR 1.09 (0.8 to 1.48)54 more per 1000 (from 121 fewer to 290 more)⊕⊕○○
LOW
CRITICAL
0%0 more per 1000 (from 0 fewer to 0 more)
Depression clinician-reported measures at endpoint (Better indicated by lower values)
1randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessvery serious1none3539-0.80 lower (4.06 lower to 2.46 higher)⊕⊕○○
LOW
CRITICAL
1

Single study, inconclusive effect size

From: APPENDIX 16, CLINICAL EVIDENCE PROFILES

Cover of Depression
Depression: The Treatment and Management of Depression in Adults (Updated Edition).
NICE Clinical Guidelines, No. 90.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2010.
Copyright © The British Psychological Society & The Royal College of Psychiatrists, 2010.

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