Table 75Summary study characteristics of studies of duloxetine

Versus placeboVersus different dosesVersus other antidepressants
No. trials (total participants)12 RCTs (3,069)5 RCTs (1242)12 RCTs (3,367)
Study IDs
N/% female
  1. 282/65
  2. 327/74
  3. 267/69
  4. 245/67
  5. 281/73
  6. 157/67
  7. 174/62
  8. 140/64
  9. 180/62
  10. 410/65
  11. 295/70
  12. 311/60
  1. 188/73
  2. 175/62
  3. 177/62
  4. 196/70
  5. 506/64
  1. 180/73
  2. 119/67
  3. 323/71
  4. 504/66
  5. 173/62
  6. 103/64
  7. 178/62
  8. 278/60
  9. 478/70
  10. 547/65
  11. 190/70
  12. 294/72
Mean age
  1. 40
  2. 50
  3. 41
  4. 42
  5. 43
  6. 40
  7. 44
  8. 41
  9. 40
  10. 42
  11. 45
  12. 72
  1. 43
  2. 44
  3. 40
  4. 45
  5. 43
  1. 43
  2. 40
  3. 44
  4. 42
  5. 44
  6. 41
  7. 44
  8. 42
  9. 38
  10. 42
  11. 45
  12. 45
Duloxetine dose
1–4.

60 mg

5.

80 mg, 120 mg

6.

40–120 mg

7.

40 mg*, 80 mg

8.

120 mg

9.

40 mg*, 80 mg

10.

60 mg

11.

80 mg, 120 mg

12.

60 mg

1.

80 mg versus 120 mg

2–3.

40 mg versus 80 mg

4.

80 mg versus 120 mg

5.

30 mg versus 60 mg

1.

80 mg

2.

40–120 mg

3–4.

60 mg

5.

80 mg

6.

120 mg

7.

80 mg

8–10.

60 mg

11.

80 mg

12.

60 mg

ComparatorPlaceboDuloxetine (doses as above)
  1. Venlafaxine 150 mg, 75 mg
SettingOutpatientsOutpatientsOutpatients
Length of treatment
1.

9 weeks

2.

8 weeks

3–4.

9 weeks

5.

8 weeks

6.

10 weeks

7–12.

8 weeks

1–4.

8 weeks

5.

6 weeks

1.

9 weeks

2.

8 weeks

3–4.

12 weeks

5.

8 weeks

6.

10 weeks

7–12.

8 weeks

Continuation phase (length and inclusion criterion)
5.

6 months for partial responders

6.

6 months but data not available

11.

6 months for partial responders

1.

6 months for partial responders

2.

6 months but data not available

4.

6 months for partial responders

5.

Non-responders re-randomised (data in Chapter 12, Section 12.3)

1.

6 months for partial responders

2.

6 months but data not available

11.

6 months for partial responders

*

Data not used as dose given less than licensed dose;

4-armed trial;

3-armed trial.

From: 10, PHARMACOLOGICAL INTERVENTIONS

Cover of Depression
Depression: The Treatment and Management of Depression in Adults (Updated Edition).
NICE Clinical Guidelines, No. 90.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2010.
Copyright © The British Psychological Society & The Royal College of Psychiatrists, 2010.

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