Table 134Summary evidence profile for active treatment comparisons for studies where fewer than 100% (but at least 50%) participants have dysthymia (acceptability/tolerability)

SSRI versus other antidepressantSSRI versus antipsychoticTCA versus other antidepressantTCA versus antipsychotic
Leaving treatment early for any reasonRR 0.67 (0.22 to 2.07) (16.7% versus 25%)RR 1.36 (0.98 to 1.89) (22.7% versus 16.7%)RR 1.22 (0.35 to 4.17) (13.5% versus 11.1%)RR 1.07 (0.81 to 1.42) (47.1% versus 44%)
Quality of evidenceLowModerateLowLow
Number of studies/ participants (comparison)K = 1; n = 48 (fluvoxamine versus maprotiline)K = 2; n = 594 (SSRI versus amisulpride)K = 1; n = 73 (imipramine versus phenelzine)K = 1; n = 253 (amitriptyline versus amisulpride)
Forest plot numberPharm subthreshold 04.01Pharm subthreshold 04.01Pharm subthreshold 04.02Pharm subthreshold 04.02
Leaving treatment early due to side effectsNot reportedRR 0.97 (0.55 to 1.7) (7.5% versus 7.7%)Not reportedRR 0.91 (0.47 to 1.78) (12.6% versus 13.9%)
Quality of evidenceLowLow
Number of studies/ participants (comparison)K = 2; n = 594 (sertraline/fluoxetine versus amisulpride)K = 1; n = 253 (amitriptyline versus amisulpride)
Forest plot numberPharm subthreshold 04.04Pharm subthreshold 04.05

From: 13, THE MANAGEMENT OF SUBTHRESHOLD DEPRESSIVE SYMPTOMS

Cover of Depression
Depression: The Treatment and Management of Depression in Adults (Updated Edition).
NICE Clinical Guidelines, No. 90.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2010.
Copyright © The British Psychological Society & The Royal College of Psychiatrists, 2010.

All rights reserved. No part of this book may be reprinted or reproduced or utilised in any form or by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying and recording, or in any information storage or retrieval system, without permission in writing from the publishers. Enquiries in this regard should be directed to the British Psychological Society.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.