Table 134Summary evidence profile for active treatment comparisons for studies where fewer than 100% (but at least 50%) participants have dysthymia (acceptability/tolerability)

SSRI versus other antidepressantSSRI versus antipsychoticTCA versus other antidepressantTCA versus antipsychotic
Leaving treatment early for any reasonRR 0.67 (0.22 to 2.07) (16.7% versus 25%)RR 1.36 (0.98 to 1.89) (22.7% versus 16.7%)RR 1.22 (0.35 to 4.17) (13.5% versus 11.1%)RR 1.07 (0.81 to 1.42) (47.1% versus 44%)
Quality of evidenceLowModerateLowLow
Number of studies/ participants (comparison)K = 1; n = 48 (fluvoxamine versus maprotiline)K = 2; n = 594 (SSRI versus amisulpride)K = 1; n = 73 (imipramine versus phenelzine)K = 1; n = 253 (amitriptyline versus amisulpride)
Forest plot numberPharm subthreshold 04.01Pharm subthreshold 04.01Pharm subthreshold 04.02Pharm subthreshold 04.02
Leaving treatment early due to side effectsNot reportedRR 0.97 (0.55 to 1.7) (7.5% versus 7.7%)Not reportedRR 0.91 (0.47 to 1.78) (12.6% versus 13.9%)
Quality of evidenceLowLow
Number of studies/ participants (comparison)K = 2; n = 594 (sertraline/fluoxetine versus amisulpride)K = 1; n = 253 (amitriptyline versus amisulpride)
Forest plot numberPharm subthreshold 04.04Pharm subthreshold 04.05


Cover of Depression
Depression: The Treatment and Management of Depression in Adults (Updated Edition).
NICE Clinical Guidelines, No. 90.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2010.
Copyright © The British Psychological Society & The Royal College of Psychiatrists, 2010.

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