Table 130Summary study characteristics of studies comparing active treatments for dysthymia

Antidepressants versus antidepressantsAntidepressants versus antipsychotics
No. trials (Total participants)6 RCTs (383)5 RCTs (1237)
Study IDs
N/% female
  1. 50/48
  2. 48/60
  3. 67/81
  4. 274/65
  5. 73/71
  6. 211/71
  1. 313/68
  2. 323/75
  3. 67/78
  4. 253/64
  5. 281/65
Mean age (range if not given)
1.

38

2.

40

3.

55

4–5.

42

6.

41

1.

47

2–3.

48

4.

47

5.

55

Drugs
1.

Imipramine versus ritanserin

2.

Fluvoxamine versus maprotiline

3.

Imipramine versus minaprine

4–5.

Sertraline versus imipramine

6.

Imipramine versus moclobemide

  1. Amisulpride versus sertraline
  2. Amisulpride versus amineptine
  3. Flupentixol versus ritanserin
  4. Amisulpride versus amitriptyline
  5. Amisulpride versus fluoxetine
Setting
1–6.

Outpatients

1–2.

Outpatients

3.

Primary care

4–5.

Outpatients

Length of treatment
1.

7 weeks

2–3.

6 weeks

4.

12 weeks

5.

7 weeks

6.

8 weeks

1–2.

12 weeks

3.

6 weeks

4.

6 months

5.

12 weeks

*

Studies have fewer than 100% of participants with dysthymia (AMORE2001 11% double depression; DEJONGHE1991 46% major depression; RAVIZZA1999 2% major depression in partial remission; SMERALDI1996 6% MDD in partial remission);

N with dysthymia in relevant antidepressant and placebo groups;

Mixed sample but dysthymia group only extracted here (VALLEJO1987 dysthymia group extracted for efficacy data; mixed sample extracted for attrition data).

From: 13, THE MANAGEMENT OF SUBTHRESHOLD DEPRESSIVE SYMPTOMS

Cover of Depression
Depression: The Treatment and Management of Depression in Adults (Updated Edition).
NICE Clinical Guidelines, No. 90.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2010.
Copyright © The British Psychological Society & The Royal College of Psychiatrists, 2010.

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