Bibliographic informationStudy type and evidence levelStudy detailsParticipant characteristicsIntervention and comparisonOutcome measures, follow-up and effect sizeComments
Sebodo 1982167
location: Indonesia
Study Type RCT

Evidence Level 1−
Total no. of patients
n= 39
Randomised in two arms:

Intervention group n = 16

Control group n = 23
Children with acute GE and severe dehydration aged between 1 ½ months and 10 years

Exclusion criteria
Acute GE due to Entamoeba histolytica
Activated charcoal
3×166 mg: up to 6 months
3×250 mg: from 6 to 12 months
3×375 mg: from 1 to 2 years
3×500 mg: from 2 to 5 years
3×500 mg: more than 5 years
The activated charcoal was given until a day after the cessation of the diarrhoea
Ringer lactate solution + OGE + activated charcoal vs ringer lactate solution + OGE
Not stated

Duration diarrhoea
Total ORS
Total IV fluids

Effect size (mean+−SD)

Duration diarrhoea (days)
Intervention gp 2.125+−0.8
Control gp 3+−1.17

Total ORS (pack)
Intervention gp 3.25+−2.08
Control gp 5.43+−3.22

Total IV fluids (bottle)
Intervention gp 3.19+−1.17
Control gp 3.74+−2.30
Study poorly reported (Method of randomisation, allocation concealment, follow-up, baseline comparability of the two groups)

From: Evidence tables

Cover of Diarrhoea and Vomiting Caused by Gastroenteritis
Diarrhoea and Vomiting Caused by Gastroenteritis: Diagnosis, Assessment and Management in Children Younger than 5 Years.
NICE Clinical Guidelines, No. 84.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2009 Apr.
Copyright © 2009, National Collaborating Centre for Women’s and Children’s Health.

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