Table 7Dementia head-to-head studies contributing to analysis

Author, YearSubjectsNTreatmentsDurationOutcomes
Deberdt et al. 2004116Age >= 40, AD, vascular or mixed dementia, NPI or NPI/NH >= 6 sum of hallucinations and delusional items494Placebo

Olanzapine-5.2 mg

Risperidone-1.0 mg
10 weeksTotal/Global score:
Olanzapine vs Risperidone-SMD = 0.10 (-0.10, 0.30)

Psychosis score:
Olanzapine vs Risperidone-SMD = -0.03 (-0.23, 0.17)

Agitation score:
Olanzapine vs Risperidone-SMD = -0.04 (-0.24, 0.16)
Schneider, et al. 2006148
Sultzer et al. 2008119
AD or probable AD, MMSE 5-26, psychosis, aggression, or agitation previous week or at least intermittently for 4 weeks, had a severity rating of at least “moderate” for conceptual disorganization, suspiciousness, or hallucinatory behavior on (BPRS), ambulatory and living at home or in an assisted-living facility421Placebo

Olanzapine 5.5mg/day

Quetiapine 56.5 mg/day

Risperidone 1.0 mg/day
12 weeksTotal/Global score:
Olanzapine vs Risperidone-SMD = -0.27 (-0.56, 0.02)

Quetiapine vs Risperidone-SMD = -0.24 (-0.53, 0.06)

Psychosis score:
Olanzapine vs Risperidone-SMD = -0.27 (-0.56, 0.02)

Quetiapine vs Risperidone-SMD = -0.24 (-0.54, 0.05)

Agitation score:
Olanzapine vs Risperidone-SMD = -0.17 (-0.12, 0.16)

Quetiapine vs Risperidone-SMD = 0.10 (-0.20, 0.39)
Rainer et al. 200714255-85 years old, dementia, MMSE score 10-26, have an NPI part I score in sub-items relating to delusions, hallucinations, agitation / aggression72Quetiapine 50-400 mg/day

Risperidone 0.5-4 mg/day
8 weeksTotal/Global score:
Quetiapine vs Risperidone-SMD = -0.06 (-0.55, 0.43)

Agitation score:
Quetiapine vs Risperidone-SMD = -0.17 (-0.66, 0.32)

AD = Alzheimer's disease; BPRS = Brief Psychiatric Rating Scale; MMSE = ; NPI = Neuropsychiatric Inventory; SMD = standardized mean difference

From: Results

Cover of Off-Label Use of Atypical Antipsychotics: An Update
Off-Label Use of Atypical Antipsychotics: An Update [Internet].
Comparative Effectiveness Reviews, No. 43.
Maglione M, Maher AR, Hu J, et al.

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