Table 5.11.3AHI (events/hr) in randomized controlled trials of mandibular advancement devices vs. mandibular advancement devices

Study
PMID
Baseline AHI (SD) [eligibility]Baseline ESS (SD)Duration (design)OutcomeInterventionsn EventN TotalOutcome MetricResult *95% CIP BtwDropout, %Study Quality
Campbell 2009219
18989715
25 (7) [10–40]11.6 (4.7)6 wk (PL)AHI<5MAD objective 3.912%33.0 vs. 12.5ndNS6B
MAD subjective 1.916
Improvement percentage §MAD objective **5.012%42.0 vs. 56.2ndNS
MAD subjective ††8.916
Failure percentage ‡‡MAD objective §§3.012%25.0 vs. 31.2ndNS
MAD subjective ***4.916
*

Top row intervention vs. bottom row intervention.

objective adjustment at 3 weeks following PSG-based feedback

self-adjustment of mandibular advancement device during the entire study duration (6 weeks)

§

>50% reduction in AHI but still >5/hr

**

objective adjustment at 3 weeks following PSG-based feedback

††

self-adjustment of mandibular advancement device during the entire study duration (6 weeks)

‡‡

AHI decreased by <50%

§§

objective adjustment at 3 weeks following PSG-based feedback

***

self-adjustment of mandibular advancement device during the entire study duration (6 weeks)

From: Appendix D, Summary Tables

Cover of Diagnosis and Treatment of Obstructive Sleep Apnea in Adults
Diagnosis and Treatment of Obstructive Sleep Apnea in Adults [Internet].
Comparative Effectiveness Reviews, No. 32.
Balk EM, Moorthy D, Obadan NO, et al.

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