Table 5.9.4bArousal index (events/hr) in randomized controlled trials of mandibular devices vs. control

Study
PMID
Baseline AHI (SD) [eligibility]Baseline ESS (SD)Duration (design)InterventionsNo. AnalyzedBaseline (SD)Change (final)Net diff or Diff95% CIP BtwDropout, %Study Quality
Bloch 2000210
10903249
27 (16) [≥5]11.9 (3.9)1 wk (XO)MAD-1 piece2436 (4.3)26.5−14.5−22.6, −6.4 *<0.050B
No treatment2436 (4.3)41
MAD-2 piece2436 (4.3)30.9−10.1−17.9, −2.3 NS
No treatment2436 (4.3)41
Barnes 2004140
15201136
21 (13) [nd]10.7 (4.1)3 mo (XO)Mandibular advancement splint8022.0 (1.2)1.8−1.4−3.6, 0.8 NS14B
Placebo tablet8022.0 (1.2)3.2
Lam 2007129
17121868
19 (11) [5–40]12 (5.7)10 wk (PL)MAD + conservative management3424.5 (2.2)−2.9−8.2−14.8, −1.6 §<0.0513B
Conservative management3323.5 (2.2)5.3
*

Estimated from reported data.

Estimated from reported data.

Estimated from reported data.

§

Estimated from reported data.

From: Appendix D, Summary Tables

Cover of Diagnosis and Treatment of Obstructive Sleep Apnea in Adults
Diagnosis and Treatment of Obstructive Sleep Apnea in Adults [Internet].
Comparative Effectiveness Reviews, No. 32.
Balk EM, Moorthy D, Obadan NO, et al.

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