Table 5.25.1Positive airway pressure devices, reported major adverse events *

Study
PMID
Intervention detailsFollowup durationNo. AnalyzedAdverse eventn%
Robinson, 2009259
19643262
CPAP2–4 mo73Claustrophobia11.4%
Hukins, 2004183
15683142
CPAP2 mo55Pressure intolerance59.2%
AutoCPAP23.6%
Salgado, 2008207
18982206
AutoCPAP, humidified4 wk17Epistaxis00
AutoCPAP, nonhumidified2229.1%
Khanna, 2003173
14592306
Nasal CPAP1 mo17Excessive nasal dryness212%
17Epistaxis212%
2 mo15Excessive pressure213%
13Severe claustrophobia323%
Oral CPAP1 mo21Excessive oral dryness1152%
21Severe gum pain314%
21Excessive pressure419%
Nussbaumer, 2006179
16537862
AutoCPAP1 mo34Claustrophobia12.9%
Anderson, 2003171
14572126
Nasal CPAP1 mo21Claustrophobia14.8%
Oral CPAP1 mo21Dry mouthr/throat (major problem)314%
Excess salivation (major problem)14.8%
Sore gums/lips (major problem)29.5%
*

Reporting of no events excluded (unless N≥100), except Salgado 2008 because the direct comparison between humidified and nonhumidified CPAP was reported.

Other adverse events (or side effects or harms) reported by studies included: skin irritation, nasal irritation or obstruction, dry nose or mouth, excess salivation, minor or moderate sore gums or lips, minor aerophagia, abdominal distension, minor chest wall discomfort, pressure discomfort, and transient or minor epistaxis.

From: Appendix D, Summary Tables

Cover of Diagnosis and Treatment of Obstructive Sleep Apnea in Adults
Diagnosis and Treatment of Obstructive Sleep Apnea in Adults [Internet].
Comparative Effectiveness Reviews, No. 32.
Balk EM, Moorthy D, Obadan NO, et al.

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