Table 5.23.8Minimum oxygen saturation (%) in randomized controlled trials of drug interventions

Study
PMID
Baseline AHI (SD) [eligibility]Baseline ESS (SD)Duration (design)InterventionsNo. AnalyzedBaseline (SD)Change (final)Net Diff or Diff95% CIP BtwDropout, %Study Quality
Carley 2007264
17310863
23 (17) [nd]nd7 d (XO)Mirtazapine 4.5 mg12nd81.1−0.6ndNS0B
Mirtazapine 15 mg12nd80.8−0.9ndNS
Placebo12nd81.7
Kiely 2004265
14694248
26.5 * (26.9) 12 (nd)4 wk (XO)Fluticasone13nd2.1−0.1ndNS0B
Placebo13nd2.2
Whyte 1988267
3067313
nd [>15]nd2 wk (XO)Acetazolamide10nd722ndnd0C
Protriptyline10nd777ndnd
Placebo10nd70

From: Appendix D, Summary Tables

Cover of Diagnosis and Treatment of Obstructive Sleep Apnea in Adults
Diagnosis and Treatment of Obstructive Sleep Apnea in Adults [Internet].
Comparative Effectiveness Reviews, No. 32.
Balk EM, Moorthy D, Obadan NO, et al.

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