Table 5.12.5dSlow wave sleep (% TST) in randomized controlled trials of mandibular advancement devices vs. CPAP

Study
PMID
Baseline AHI (SD) [eligibility]Baseline ESS (SD)Duration (design)InterventionsNo. AnalyzedBaseline (SD)Final (SD)Net diff or Diff95% CIP BtwDropout, %Study Quality
Hoekema 2008230
18719218
40 (28) [≥5]14.2 (5.6)78 d [IQR = 60–88 d] (PL)MAD51/47 *13.7 (9.0)20.4 (7.7)−2.1−5.8, 1.6 NS 4B
CPAP52/4713.0 (11.5)21.8 (8.0)
Barnes 2004140
15201136
21 (12) [nd]10.7 (3.6)3 mo (XO)MAD8017.9 (10.7)20.1 (9.8)−0.6−2.8, 1.6 §NS23B
CPAP20.7 (9.8)
Randerath 2002228
12171833
18 (8) [5–30]nd6 wk (XO)MAD2014.2 (10.6)14.1 (10.8)−2.1−6.5, 2.3 **NS0B
CPAP16.2 (9.1)
Clark 1996224
8769497
34 (14) [≥10]nd2 wk (XO)MAD2112.4 (7.8)13.4 (8.0)−1.8−4.9, 1.2 ††nd4C
CPAP15.2 (5.6)
Skinner 2004232
14718430
29 (13) [10–60]13.2 (4.9)1 mo (XO)CMS collar1020.4 (8.2)20.1 (13.4)−3.9−11.2, 3.4 ‡‡0.300C
AutoCPAP24.0 (8.9)
*

Baseline/Final

Estimated from reported SD’s.

Statistical analysis of comparison of final values.

§

Estimated from reported SE’s.

**

Estimated from reported SD’s.

††

Estimated from reported SD’s.

‡‡

Estimated from reported SD’s.

From: Appendix D, Summary Tables

Cover of Diagnosis and Treatment of Obstructive Sleep Apnea in Adults
Diagnosis and Treatment of Obstructive Sleep Apnea in Adults [Internet].
Comparative Effectiveness Reviews, No. 32.
Balk EM, Moorthy D, Obadan NO, et al.

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