Table 1.11-1Enuresis alarm compared to DBT for children resistant to enuresis alarms - Clinical study characteristics

OutcomeNumber of studiesDesignLimitationsInconsistencyIndirectnessImprecision
Number of children who achieved 14 consecutive dry nights2randomised trialvery serious1,2no serious inconsistencyno serious indirectnessserious3
Mean number of wet nights per week at the end of treatment (no sd)2randomised trialvery serious1,4no serious inconsistencyno serious indirectnessserious5
Number of children who relapsed2randomised trialvery serious1,2no serious inconsistencyno serious indirectnessserious3
Number of children who dropped out1randomised trialvery serious1,6no serious inconsistencyno serious indirectnessserious3

Studies had unclear allocation concealment and blinding


Result from Butler (1988) from Cochrane review


The confidence interval crosses the MID(s)


Results from Butler (1988) and Butler (1990) taken from the Cochrane review


No information on variability was given in the study, therefore calculation of standard deviation was not possible


The study had unclear allocation concealment and blinding

From: Appendix H, GRADE profile tables

Cover of Nocturnal Enuresis
Nocturnal Enuresis: The Management of Bedwetting in Children and Young People.
NICE Clinical Guidelines, No. 111.
National Clinical Guideline Centre (UK).
Copyright © 2010, National Clinical Guideline Centre.

Apart from any fair dealing for the purposes of research or private study, criticism or review, as permitted under the Copyright, Designs and Patents Act, 1988, no part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

The rights of the National Clinical Guideline Centre to be identified as Author of this work have been asserted by them in accordance with the Copyright, Designs and Patents Act, 1988.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.