Table 1.8-25Imipramine compared to placebo - Clinical study characteristics

OutcomeNumber of studiesDesignLimitationsInconsistencyIndirectnessImprecision
Number of children with anxiety1randomised trialvery serious1seriousno serious indirectnessserious2
Number of children with lethargy1randomised trialserious3,4no serious inconsistencyno serious indirectnessvery serious2,5
Number of children with sleep disturbances1randomised trialvery serious1no serious inconsistencyno serious indirectnessserious2
Number of children with dizziness1randomised trialserious3,4no serious inconsistencyno serious indirectnessserious2
Number of children with giddiness1randomised trialvery serious1no serious inconsistencyno serious indirectnessserious2
Number of children with dizziness and dry mouth1randomised trialserious3,4no serious inconsistencyno serious indirectnessserious2
Number of children with gastrointestinal1randomised trialvery serious1,4no serious inconsistencyno serious indirectnessvery serious2,5
Number of children with upset stomach1randomised trialserious3no serious inconsistencyno serious indirectnessvery serious2,5
Number of children with abdominal pain2randomised trialno serious limitationsno serious inconsistencyno serious indirectnessserious2
Number of children with abdominal pain and epistaxis1randomised trialvery serious1no serious inconsistencyno serious indirectnessserious2
Number of children with vomiting and drowsiness leading to withdrawal1randomised trialserious3,4no serious inconsistencyno serious indirectnessserious2
Number of children with vomiting, sweating and sickness1randomised trialserious3,4no serious inconsistencyno serious indirectnessserious2
Number of children with anorexia1randomised trialserious3,4no serious inconsistencyno serious indirectnessserious2
Number of children with weight loss1randomised trialserious1no serious inconsistencyno serious indirectnessserious2
Number of children with constipation1randomised trialserious3,4no serious inconsistencyno serious indirectnessvery serious2
1
2

The confidence interval crosses the MID(s)

3
4

Results taken from the Cochrane review

5

Wide confidence interval - strong uncertainty of where the effect lies

From: Appendix H, GRADE profile tables

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