Table 1.8-1Imipramine compared to placebo - Clinical study characteristics

OutcomeNumber of studiesDesignLimitationsInconsistencyIndirectnessImprecision
Number of children who achieved 14 consecutive dry nights6randomised trialvery serious1,2no serious inconsistencyno serious indirectnessno serious imprecision
Number of children who had >80% improvement at the end of treatment1randomised trialvery serious3no serious inconsistencyno serious indirectnessserious4
Number of children who showed >50% improvement in the number of dry nights2randomised trialvery serious5no serious inconsistencyno serious indirectnessserious5
Mean number of wet nights per week at the end of treatment1randomised trialserious6,7no serious inconsistencyno serious indirectnessserious4
Mean number of wet nights per week at the end of treatment (no sd)6randomised trialvery serious5,8no serious inconsistencyno serious indirectnessserious9
Mean number of wet nights per 2 weeks during treatment1randomised trialserious6,10no serious inconsistencyno serious indirectnessserious4
Mean number of wet nights during 26 nights of treatment1randomised trialvery serious3no serious inconsistencyno serious indirectnessno serious imprecision
Mean number of wet nights per week at follow up1randomised trialserious6,7no serious inconsistencyno serious indirectnessserious4
Mean number of wet nights per week at follow up (no sd)1randomised trialvery serious3no serious inconsistencyno serious indirectnessserious9
Number of children who dropped out1randomised trialvery serious3,11no serious inconsistencyno serious indirectnessvery serious4,12
1

All studies had unclear allocation concealment, 5 studies had unclear blinding

2

Results from Agarwala (1968) and Poussaint (1965) were taken from Cochrane review

3

Study had unclear allocation concealment and blinding

4

The confidence interval crosses the MID(s)

5

Studies had unclear allocation concealment and blinding

6

Study had unclear allocation concealment

7

Results from Attenburrow (1984) from taken from the Cochrane review

8

Results from Drew (1966), Fournier (1987) and Harrison (1970) taken from the Cochrane review

9

No information on variability was given in the study, therefore calculation of standard deviation was not possible and the mean difference and CI were not estimable

10

Results from Agarwala (1968) taken from the Cochrane review

11

Results from Harrison (1970) taken from the Cochrane review

12

Wide confidence interval - strong uncertainty of where the effect lies

From: Appendix H, GRADE profile tables

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