Table 16Withdrawals due to adverse events in head-to-head trials of drugs for other types of neuropathic pain

Comparison (reference)PopulationWithdrawals due to adverse eventsSpecific adverse events
Amitriptyline vs. carbamazepine39PoststrokeNoneMost frequent Amitriptyline: tiredness and dry mouth
Carbamazepine: vertigo, tiredness, gait disturbances
Amitriptyline vs. gabapentin41Spinal cord injury4/38 amitriptyline (11%)
5/38 gabapentin (13%)
P=0.72
More frequent with amitriptyline: dry mouth, constipation, difficulty emptying bowels, nausea, difficulty emptying the bladder
Imipramine vs. gabapentin46Cancer- related pain0/12 imipramine 20 mg
3/12 gabapentin 800 mg
P=0.10
More dizziness with gabapentin 800 mg than imipramine 20 mg: 4 mild, 3 severe with gabapentin 800 mg vs. 1 mild with imipramine (P=0.014)

From: Results

Cover of Drug Class Review: Neuropathic Pain
Drug Class Review: Neuropathic Pain: Final Update 1 Report [Internet].
Selph S, Carson S, Fu R, et al.
Portland (OR): Oregon Health & Science University; 2011 Jun.
Copyright © 2011 by Oregon Health & Science University.

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