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Selph S, Carson S, Fu R, et al. Drug Class Review: Neuropathic Pain: Final Update 1 Report [Internet]. Portland (OR): Oregon Health & Science University; 2011 Jun.

Appendix DExcluded studies

The following full-text publications were considered for inclusion but failed to meet the criteria for this report.

2=ineligible outcome, 3=ineligible intervention, 4=ineligible population, 5=ineligible publication type, 6= ineligible study design

Excluded studiesExclusion code
Head-to-head trials
Aldrete JA, Aldrete VT, Williams SK, Johnson S. Reduction of neuropathic pain in patients with arachnoiditis: Crossover study of gabapentin versus phenytoin. Pain Digest. 2000;10(2):64–67.4
Baron R, Mayoral V, Leijon G, et al. Efficacy and safety of 5% lidocaine (lignocaine) medicated plaster in comparison with pregabalin in patients with postherpetic neuralgia and diabetic polyneuropathy: interim analysis from an open-label, two-stage adaptive, randomized, controlled trial. Clinical Drug Investigation. 2009;29(4):231–241.6
Jann S, Muscia F, Sterzi R. Randomized, open label trial on the efficacy and tollerability of oxcarbazepione versus gabapentin in the treatment of neuropathic pain. Journal of the Peripheral Nervous System : JPNS. 2007;12(2):160–161.5
Park JH, Lee SH, Kim ST. Pharmacologic management of trigeminal nerve injury pain after dental implant surgery. International Journal of Prosthodontics. Jul–Aug 2010;23(4):342–346.6
Rowbotham MC, Reisner LA, Davies PS, Fields HL. Treatment response in antidepressant-naive postherpetic neuralgia patients: double-blind, randomized trial. Journal of Pain. Nov 2005;6(11):741–746.6
Turkington RW. Depression masquerading as diabetic neuropathy. JAMA. Mar 21 1980;243(11):1147–1150.6
Active-control trials
Backonja M, Wallace M, Blonsky E, et al. NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: A randomized, double-blind study. . Lancet Neurol. 2008 7(12):1106–1112.3
Dworkin RH, Barbano RL, Tyring SK, et al. A randomized, placebo-controlled trial of oxycodone and of gabapentin for acute pain in herpes zoster. Pain. Apr 2009;142(3):209–217.4
Gatti A, Sabato AF, Occhioni R, et al. Controlled-release oxycodone and pregabalin in the treatment of neuropathic pain: results of a multicenter Italian study. European Neurology. 2009;61(3):129–137.6
Giannopoulos S, Kosmidou M, Sarmas I, et al. Patient compliance with SSRIs and gabapentin in painful diabetic neuropathy. Clinical Journal of Pain. Mar–Apr 2007;23(3):267–269.6
Ho KY, Huh BK, White WD, et al. Topical amitriptyline versus lidocaine in the treatment of neuropathic pain. Clinical Journal of Pain. Jan 2008;24(1):51–55.3
Irving G, Backonja M, Dunteman E, et al. A Multicenter, Randomized, Double-Blind, Controlled Study of NGX-4010, a High-Concentration Capsaicin Patch, for the Treatment of Postherpetic Neuralgia. Pain Med. 2011 12(1):99–109.3
Kadiroglu AK, Sit D, Kayabasi H, et al. The effect of venlafaxine HCl on painful peripheral diabetic neuropathy in patients with type 2 diabetes mellitus. Journal of Diabetes & its Complications. Jul–Aug 2008;22(4):241–245.6
Kvarnstrom A, Karlsten R, Quiding H, Gordh T. The analgesic effect of intravenous ketamine and lidocaine on pain after spinal cord injury. Acta Anaesthesiologica Scandinavica. 2004;48(4):498–506.3
Nalamachu S, Crockett RS, Mathur D. Lidocaine patch 5% for carpal tunnel syndrome: how it compares with injections: a pilot study. Journal of Family Practice. Mar 2006;55(3):209–214.4
Ruessmann HJ, German Society of out patient diabetes centres AND. Switching from pathogenetic treatment with alpha-lipoic acid to gabapentin and other analgesics in painful diabetic neuropathy: a real-world study in outpatients. Journal of Diabetes & its Complications. May–Jun 2009;23(3):174–177.6
Solak O, Metin M, Esme H, et al. Effectiveness of gabapentin in the treatment of chronic post-thoracotomy pain. European Journal of Cardio-Thoracic Surgery. Jul 2007;32(1):9–12.6
Placebo-controlled trials
Backonja MM. Gabapentin monotherapy for the symptomatic treatment of painful neuropathy: a multicenter, double-blind, placebo-controlled trial in patients with diabetes mellitus. Epilepsia. 1999;40 Suppl 6:S57–59; discussion S73–54.5
Beydoun A, Wan Y, Hopwood M, Liebel J. Results of a randomized, placebo-controlled trial suggest oxcarbazepine has a therapeutic effect in the treatment of painful diabetic neuropathy. European Journal of Neurology. 2004;11(Suppl 2):101.5
Bongardt S, Bain S, Tzschaschel B, Sommerville K. Lacosamide reduces pain in a randomized, controlled trial of subjects with diabetic neuropathic pain. Poster presented at 12th World Congress on Pain (WCP) of The International Association for The Study of Pain (IASP). August 17–22, 2008. Glasgow, UK.6
Caraceni A, Zecca E, Bonezzi C, et al. Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group. Journal of Clinical Oncology. Jul 15 2004;22(14):2909–2917.4
Carlsson KC, Hoem NO, Moberg ER, Mathisen LC. Analgesic effect of dextromethorphan in neuropathic pain. Acta anaesthesiologica Scandinavica. 2004;48(3):328–336.3
Edwards KR, Bennington V, Marykay S, Hes M, LaMoreaux E, Harofolo E. Gabapentin for pain associated with diabetic peripheral neuropathy. A double-blind, placebo controlled study (945–2100). Neurology. 1998.5
Eisenberg E, Lurie Y, Brecker C, Daoud D, Ishay A. Lamotrigine in the treatment of painful diabetic neuropathy: A randomized, placebo-controlled study. Progress in Pain Research and Management. 2000;16:857–862.5
Estanislao L, Carter K, McArthur J, Olney R, Simpson D, Lidoderm HIVNG. A randomized controlled trial of 5% lidocaine gel for HIV-associated distal symmetric polyneuropathy. Journal of Acquired Immune Deficiency Syndromes: JAIDS. Dec 15 2004;37(5):1584–1586.3
Forssell H, Tasmuth T, Tenovuo O, Hampf G, Kalso E. Venlafaxine in the treatment of atypical facial pain: a randomized controlled trial. Journal of Orofacial Pain. 2004;18(2):131–137.4
Hidvégi T, Bretschneider M, Bongardt S, Koch B. Lacosamide in subjects with painful distal diabetic neuropathy: results of a multi-center, open-label, follow-on trial. Poster presented at American Pain Society (APS) 25th Annual Scientific Meeting. May 3–6, 2006. San Antonio, USA.6
Hidvégi T, Bretschneider M, Thierfelder S, Sommerville K, Bongardt S. Long-term efficacy of lacosamide in subjects with painful distal diabetic neuropathy: results of a double-blind, randomized withdrawal trial. Poster presented at 27th Annual Scientific Meeting of The American Pain Society (APS), May 8–10, 2008. Tampa, USA.6
Irving G, Jensen M, Cramer M, et al. Efficacy and tolerability of gastric-retentive gabapentin for the treatment of postherpetic neuralgia: results of a double-blind, randomized, placebo-controlled clinical trial. Clinical Journal of Pain. Mar–Apr 2009;25(3):185–192.3
Kanai A, Kumaki C, Niki Y, et al. Efficacy of a metered-dose 8% lidocaine pump spray for patients with post-herpetic neuralgia. Pain Medicine. Jul–Aug 2009;10(5):902–909.3
Kanai A, Segawa Y, Okamoto T, et al. The analgesic effect of a metered-dose 8% lidocaine pump spray in posttraumatic peripheral neuropathy: a pilot study. Anesthesia & Analgesia. Mar 2009;108(3):987–991.3
Kenney P, Simpson J, Koch B, Sp768 Study G. A Multi-center, randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of lacosamide (200, 400, and 600 mg/day) in subjects with painful distal diabetic neuropathy. Journal of Pain. no: 774, 2006 2006;7(4, Suppl 1):S45.5
Khoromi S, Patsalides A, Parada S, Salehi V, Meegan JM, Max MB. Topiramate in chronic lumbar radicular pain. Journal of Pain. Dec 2005;6(12):829–836.6
Kimos P, Biggs C, Mah J, et al. Analgesic action of gabapentin on chronic pain in the masticatory muscles: a randomized controlled trial. Pain. 2007;127(1–2):151–160.4
Loubser PG, Donovan WH. Diagnostic spinal anaesthesia in chronic spinal cord injury pain. Paraplegia. 1991;29(1):25–36.3
Max MB, Lynch SA, Muir J, Shoaf SE, Smoller B, Dubner R. Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. New England Journal of Medicine. May 7 1992;326(19):1250–1256.3
McQuay HJ, Carroll D, Jadad AR, et al. Dextromethorphan for the treatment of neuropathic pain: a double-blind randomised controlled crossover trial with integral n-of-1 design. Pain. Oct 1994;59(1):127–133.3
Maier C, Baron R, Jensen TS, Bongardt S, Koch B, Rauschkolb C. A pilot randomized, double-blind, placebo-controlled trial to investigate safety and efficacy of SPM 927 in postherpetic neuralgia. Poster presented at 6th International Conference on the Mechanisms and Treatment of Neuropathic Pain (ICMTNP), Sept.18–20, 2003. San Francisco, USA.6
Mendel CM, Klein RF, Chappell DA, et al. A trial of amitriptyline and fluphenazine in the treatment of painful diabetic neuropathy. JAMA. Feb 7 1986;255(5):637–639.3
Mercadante S, Arcuri E, Tirelli W, Villari P, Casuccio A. Amitriptyline in neuropathic cancer pain in patients on morphine therapy: a randomized placebo-controlled, double-blind crossover study. Tumori. May–Jun 2002;88(3):239–242.4
Nelson KA, Park KM, Robinovitz E, Tsigos C, Max MB. High-dose oral dextromethorphan versus placebo in painful diabetic neuropathy and postherpetic neuralgia. Neurology. May 1997;48(5):1212–1218.3
Nicol CF. A four year double-blind study of tegretol in facial pain. Headache. Apr 1969;9(1):54–57.4
Nikolajsen L, Finnerup NB, Kramp S, Vimtrup A-S, Keller J, Jensen TS. A randomized study of the effects of gabapentin on postamputation pain. Anesthesiology. Nov 2006;105(5):1008–1015.4
Pandey CK, Bose N, Garg G, et al. Gabapentin for the treatment of pain in guillain-barre syndrome: a double-blinded, placebo-controlled, crossover study. Anesthesia & Analgesia. of contents, 2002 Dec 2002;95(6):1719–1723.4
Pfizer CT. Efficacy of pregabalin in subjects with post-stroke central neuropathic pain. 2006.5
Renno SI, Rao RD, Sloan J, et al. The efficacy of lamotrigine in the management of chemotherapy-induced peripheral neuropathy: A phase III randomized, double blind, placebo-controlled NCCTG trial, N01C3 [abstract] 2006. Journal of Clinical Oncology : ASCO annual meeting proceedings. 2006;24(18S Part I):475.5
Rowbotham MC, Davies PS, Fields HL. Topical lidocaine gel relieves postherpetic neuralgia. Annals of Neurology. Feb 1995;37(2):246–253.3
Sandercock D, Cramer M, Wu J, et al. Gabapentin extended release for the treatment of painful diabetic peripheral neuropathy: efficacy and tolerability in a double-blind, randomized, controlled clinical trial. Diabetes Care. Feb 2009;32(2):e20.3
Simpson DM, Schifitto G, Clifford DB, et al. Pregabalin in the treatment of painful HIV neuropathy: A randomized, double-blind, placebo-controlled trial. Neurology. 2009;72(11 Suppl 3):A202–203.5
Sindrup SH, Bach FW, Gram LF. Plasma beta-endorphin is not affected by treatment with imipramine or paroxetine in patients with diabetic neuropathy symptoms. Clinical Journal of Pain. Jun 1992;8(2):145–148.2
Sindrup SH, Bjerre U, Dejgaard A, Brosen K, Aaes-Jorgensen T, Gram LF. The selective serotonin reuptake inhibitor citalopram relieves the symptoms of diabetic neuropathy. Clinical Pharmacology & Therapeutics. Nov 1992;52(5):547–552.3
Sindrup SH, Gram LF, Brosen K, Eshoj O, Mogensen EF. The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms. Pain. Aug 1990;42(2):135–144.3
Sindrup SH, Tuxen C, Gram LF, et al. Lack of effect of mianserin on the symptoms of diabetic neuropathy. European Journal of Clinical Pharmacology. 1992;43(3):251–255.3
Skljarevski V, Ossanna M, Liu-Seifert H, et al. A double-blind, randomized trial of duloxetine versus placebo in the management of chronic low back pain. European Journal of Neurology. Sep 2009;16(9):1041–1048.4
UCB Pharma SA. A multi-center, randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of 400mg/day lacosamide in subjects with painful distal diabetic neuropathy using two different titration schemes. 2008;NCT00350103.6
UCB, Inc. Clinical Study Summary of SP690, An open-label follow-on trial to assess the long-term safety and efficacy of oral SPM 927 in subjects with postherpetic neuralgia (PHN). www​ Accessed April 20, 2011. (NCT00238511)6
UCB, Inc. Clinical Study Summary of SP874, A Multi-center, randomized, double-blind, placebo-controled Trial to Assess the Efficacy and Safety of 400 mg/day Lacosamide in Subjects with Painful Distal Diabetic Neuropathy Using Two Different Titration Schemes. www​ Accessed: April 20, 2011.6
Veldhuijzen DS, van Wijck AJ, Verster JC, et al. Acute and subchronic effects of amitriptyline 25mg on actual driving in chronic neuropathic pain patients. Journal of Psychopharmacology. Nov 2006;20(6):782–788.2
Wu EQ, Birnbaum HG, Mareva MN, et al. Cost-effectiveness of duloxetine versus routine treatment for U.S. patients with diabetic peripheral neuropathic pain. Journal of Pain. Jun 2006;7(6):399–407.6
Wymer J, Garrison C, Simpson J, Koch B, Group SPS. A multicenter, randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of lacosamide in subjects with painful distal diabetic neuropathy. Neurology. 2006;66(Suppl 2):A202.5
Wymer JM, Garrison C, Simpson J, Koch B. A multicenter, randomized double-blind, placebo-controlled trial assessing the efficacy and safety of lacosamide in painful distal diabetic neuropathy. Annals of Neurology. 2006;60(Suppl 3 (Suppl 10 on cover)):S68.5
Yelland MJ, Poulos CJ, Pillans PI, et al. N-of-1 randomized trials to assess the efficacy of gabapentin for chronic neuropathic pain. Pain Medicine. May–Jun 2009;10(4):754–761.6
Yildirim K, Sisecioglu M, Karatay S, et al. The effectiveness of gabapentin in patients with chronic radiculopathy. The Pain Clinic. 2003;15(3):213–218.4
Yucel A, Ozyalcin S, Koknel Talu G, et al. The effect of venlafaxine on ongoing and experimentally induced pain in neuropathic pain patients: a double blind, placebo controlled study. European journal of pain (London, England). 2005;9(4):407–416.6
Copyright © 2011 by Oregon Health & Science University.
Cover of Drug Class Review: Neuropathic Pain
Drug Class Review: Neuropathic Pain: Final Update 1 Report [Internet].
Selph S, Carson S, Fu R, et al.
Portland (OR): Oregon Health & Science University; 2011 Jun.


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