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Drug Class Review: Neuropathic Pain: Final Update 1 Report [Internet]

Drug Class Review: Neuropathic Pain: Final Update 1 Report [Internet]

Drug Class Reviews - Oregon Health & Science University

Version: June 2011

Evidence Tables

Gabapentin 200 mg + imipramine 10 mg every 12 hours

Results

Overall, 128 studies were included in this report (55 were identified in searches conducted for Update 1). Figure 1 shows the flow of study selection. We received dossiers from 5 pharmaceutical manufacturers: Eli Lilly, Endo, OMJUS, Ortho McNeil, and UCB. Twenty studies that were included in the original report were excluded in Update 1 either because they were outdated (8 systematic reviews) or because the inclusion criteria had changed. See Appendix D for a list of excluded studies and reasons for exclusion at full-text screening. Of the included studies, 14 were direct comparisons of drugs in this review. The remainder was placebo-controlled, observational, or systematic reviews.

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