Table 8-137Trabeculectomy vs. pharmacological treatment - Economic summary of findings

StudyIncremental cost (£)Incremental effectsICER (£/QALY)Uncertainty
Ainsworth19913cost saving (a)NRNAIncremental cost per unilateral COAG patient is £219.
Early COAG
NCC-AC model Trabeculectomy vs BB1,2300.135 QALY9,11395% CI (£/QALY): cost saving – 85,631
Results sensitive to probability of progression: if <6% per year (~0.18 dB/year) treatment with BB is more cost effective.
Results also sensitive to cost of surgery and age.
NCC-AC model Trabeculectomy vs PGA1,1340.104 QALY10,90695% CI (£/QALY): cost saving – 122,050
Results sensitive to probability of progression: if <6% per year (~0.18 dB/year) treatment with PGA is more cost effective.
Results also sensitive to cost of surgery and age.
Moderate COAG
NCC-AC model Trabeculectomy vs BB3970.2181,822If progression is <2% per year (~0.08dB/year) treatment with BB is more cost-effective.
Results are sensitive to age.
NCC-AC model Trabeculectomy vs PGA3630.165 QALY2,194If progression is <2% per year (0.08dB/year) treatment with PGA is more cost-effective.
Results are sensitive to age.
Advanced COAG
NCC-AC model Trabeculectomy vs BBcost saving0.307 QALYcost savingResults are not sensitive to progression rate or age.
NCC-AC model Trabeculectomy vs PGAcost saving0.233 QALYcost savingResults are not sensitive to progression rate or age.
a

In bilateral COAG patients.

From: 8, Treatment of chronic open angle glaucoma

Cover of Glaucoma
Glaucoma: Diagnosis and Management of Chronic Open Angle Glaucoma and Ocular Hypertension.
NICE Clinical Guidelines, No. 85.
National Collaborating Centre for Acute Care (UK).
Copyright © 2009, National Collaborating Centre for Acute Care.

Apart from any fair dealing for the purposes of research or private study, criticism or review, as permitted under the Copyright, Designs and Patents Act, 1988, no part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

The rights of National Collaborating Centre for Acute Care to be identified as Author of this work have been asserted by them in accordance with the Copyright, Designs and Patents Act, 1988.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.