Table 8-116Separate combination of prostaglandin analogues plus beta-blockers versus prostaglandin analogues - Clinical summary of findings

OutcomeInterventionControlRelative riskAbsolute effectQuality
Mean change in IOP from baseline7981not applicableMD −0.66 (−1.44 to 0.13)Very low
Number of patients with an acceptable IOP of approx <18mmHg30/45 (66.7%)32/46 (69.6%)RR 0.96 (0.72 to 1.27)28 fewer per 1000 (from 195 fewer to 188 more)Low
Number of patients experiencing a respiratory adverse event1/49 (2%)0/50 (0%)RR 3.06 (0.13 to 73.34)not estimable (a)Very low
Number of patients with hyperaemia27/79 (34.2%)18/81 (22.2%)RR 1.54 (0.98 to 2.44)120 more per 1000 (from 4 fewer to 320 more)Very low

An absolute effect calculation is not possible as there are no events in the control arm of the study.

From: 8, Treatment of chronic open angle glaucoma

Cover of Glaucoma
Glaucoma: Diagnosis and Management of Chronic Open Angle Glaucoma and Ocular Hypertension.
NICE Clinical Guidelines, No. 85.
National Collaborating Centre for Acute Care (UK).
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