ClinicalThere is no statistically significant difference between carbonic anhydrase inhibitors and no treatment in the number of patients converting to COAG at 5 years follow up. (MODERATE QUALITY)
There is no statistically significant difference between carbonic anhydrase inhibitors and no treatment in the number of patients with visual field progression at 5 years follow up. (MODERATE QUALITY)
There were no studies which reported mean change in IOP from baseline expressed as an absolute value with standard deviation.
Carbonic anhydrase inhibitors are more effective than no treatment in reducing the number of patients experiencing an IOP increase to in excess of 35mmHg at 5 years follow up. (HIGH QUALITY)
There were no studies which reported the number of patients with an acceptable IOP.
There were no studies which reported adverse events.
EconomicNo studies meeting the inclusion criteria were identified which compared carbonic anhydrase inhibitors to no treatment.

From: 7, Treatment of ocular hypertension and suspected chronic open angle glaucoma

Cover of Glaucoma
Glaucoma: Diagnosis and Management of Chronic Open Angle Glaucoma and Ocular Hypertension.
NICE Clinical Guidelines, No. 85.
National Collaborating Centre for Acute Care (UK).
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