Table 7-35Beta-blockers vs. no treatment - Clinical summary of findings

OutcomeInterventionControlRelative riskAbsolute effectQuality
Visual field progression37/373 (9.9%)87/370 (23.5%)RR 0.77 (0.52 to 1.14)54 fewer per 1000 (from 113 fewer to 33 more)Low
Mean change in IOP from baseline319318not applicableMD −2.88 (−4.14 to −1.61)Very low
Number of patients with uncontrolled IOP (>30mmHg)6/348 (1.7%)11/342 (3.2%)RR 0.56 (0.22 to 1.46)14 fewer per 1000 (from 25 fewer to 15 more)Low
Number of patients experiencing a respiratory adverse event1/53 (1.9%)0/54 (0%)RR 3.06 (0.13 to 73.37)not estimable (a)Low
Number of patients experiencing a cardiovascular adverse event4/53 (7.5%)0/54 (0%)RR 9.17 (0.51 to 166.18)not estimable (a)Low
a

An absolute effect calculation is not possible as there are no events in the control arm of the study.

From: 7, Treatment of ocular hypertension and suspected chronic open angle glaucoma

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Glaucoma: Diagnosis and Management of Chronic Open Angle Glaucoma and Ocular Hypertension.
NICE Clinical Guidelines, No. 85.
National Collaborating Centre for Acute Care (UK).
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