Isophane insulin compared with crystalline insulin zinc suspension

StudyPopulationInterventionOutcomesResultsCommentsDesignEL
Wolfsdorf et al, 199120220 children and young people with type 1 diabetes
Aged 7–18 years
USA
Pre-breakfast and pre-evening meal mixture of isophane insulin and soluble insulin
versus
pre-breakfast mixture of isophane insulin and soluble insulin and a pre-evening meal mixture of crystalline insulin zinc suspension and soluble insulin
Trial length: two 12-week periods
  1. HbA1 level
  2. Mean fasting blood glucose levels pre-breakfast
  3. Mean blood glucose before a bedtime snack
  1. 9.1 ± 1.7% vs. 9.5 ± 1.4%, no statistical difference
  2. 10.3 ± 2.2 vs. 9.6 ± 1.9 mmol/l, p < 0.05
  3. 8.4 ± 1.9 vs. 10.0 ± 2.1 mmol/l
At no other times were the blood glucose levels different
No description of how randomisation took place
Supported by Eli Lilly
RCT crossoverIb
Zinman et al, 1999203178 adult patients with type 1 diabetes
Aged 42 ± 4 years
USA
Isophane insulin
versus
crystalline insulin zinc suspension
Trial length: 1 year
  1. HbA1c levels
  2. Rates of severe hypoglycaemia
  1. 7.6 ± 0.1% vs. 7.7 ± 0.1%, no statistical difference
  2. 0.05 ± 0.03 vs. 0.07 ± 0.04 per patient every 30 days
No description of how randomisation took place
Supported by Eli Lilly
RCT parallelIb
Parillo et al, 199220410 adult patients with type 1 diabetes
Aged 28 ± 2 years
Italy
Isophane insulin
versus
crystalline insulin zinc suspension
Trial length: 1 year
Fasting blood glucose levels At 06:00: 10.82 ± 4.27 vs. 6.26 ± 0.88 mmol/l
At 08:00: 14.03 ± 1.08 vs. 9.26 ± 1.02 mmol/l
There were no differences in blood glucose levels at any other time of day
No description of how randomisation took place
Supported by Novo Farmacutici Italia SpA
RCT crossoverIb
Riccio et al, 199420516 adult patients with type 1 diabetes.
Aged 41 ± 4 years
Italy
Isophane insulin
versus
crystalline insulin zinc suspension
Trial length: 1 year
Glycated haemoglobin8.2 ± 0.3% vs. 7.9 ± 0.4%No description of how randomisation took place
Supported by Eli Lilly
RCT crossoverIb

From: Evidence tables

Cover of Type 1 Diabetes
Type 1 Diabetes: Diagnosis and Management of Type 1 Diabetes in Children and Young People.
NICE Clinical Guidelines, No. 15.2.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2004 Sep.
Copyright © 2004, National Collaborating Centre for Women’s and Children’s Health.

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