Table 8.2LNG-IUS for treatment of HMB – non-comparative studies

Bibliographic informationStudy type and evidence levelAim of studyNo. of patientsPopulation characteristicsOutcomesResultsSource of funding and additional comments
Hurskainen 2004483randomised

EL = 3
LNG-IUS; hysterectomy236 – 119 (116 available at 12 months) to LNG-IUS, 117 (112 available at 12 months) to hysterectomywomen; menstruating; subjective menorrhagia; aged 35 to 49; completed families; Excluded if – submucous fibroids, endometrial polyps, urinary or bowel symptoms due to large fibroid, or ovarian pathology.

Country: Finland
Predictors of outcomePresence of fibroids nor age were predictors of outcome at 12 months for LNG-IUS or hysterectomy.

Multiple regression analysis showed that MBL was the most significant factor predicting outcome.

Comparison of women with and without objective menorrhagia (> 80 ml MBL).

For women in LNG-IUS group women without menorrhagia had better QoL outcomes than women with menorrhagia on: anxiety (P =0.04), EQ-5D (P = 0.05). In the hysterectomy group, women without menorrhagia had better outcomes than those with menorrhagia on: anxiety (P = 0.007), emotional well-being (P = 0.01) and energy (P = 0.0002).

Women without menorrhagia had better outcomes with LNG-IUS than women with menorrhagia on EQ-5D (P = 0.03).

Women with menorrhagia had better outcomes with hysterectomy than LNG-OUS for: anxiety (P = 0.003), general health (P = 0.04), energy (P = 0.05), and pain relief (P = 0.04).
Funding source: Not stated

Study summary: Success or failure of treatment of menorrhagia is multi-factorial, so difficult to predict in individual cases.

From: Evidence Tables

Cover of Heavy Menstrual Bleeding
Heavy Menstrual Bleeding.
NICE Clinical Guidelines, No. 44.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2007 Jan.
Copyright © 2007, National Collaborating Centre for Women's and Children's Health.

No part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK []. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.