Table 8.2LNG-IUS for treatment of HMB – non-comparative studies

Bibliographic informationStudy type and evidence levelAim of studyNo. of patientsPopulation characteristicsOutcomesResultsSource of funding and additional comments
Hurskainen 2004483randomised

EL = 3
LNG-IUS; hysterectomy236 – 119 (116 available at 12 months) to LNG-IUS, 117 (112 available at 12 months) to hysterectomywomen; menstruating; subjective menorrhagia; aged 35 to 49; completed families; Excluded if – submucous fibroids, endometrial polyps, urinary or bowel symptoms due to large fibroid, or ovarian pathology.

Country: Finland
Predictors of outcomePresence of fibroids nor age were predictors of outcome at 12 months for LNG-IUS or hysterectomy.

Multiple regression analysis showed that MBL was the most significant factor predicting outcome.

Comparison of women with and without objective menorrhagia (> 80 ml MBL).

For women in LNG-IUS group women without menorrhagia had better QoL outcomes than women with menorrhagia on: anxiety (P =0.04), EQ-5D (P = 0.05). In the hysterectomy group, women without menorrhagia had better outcomes than those with menorrhagia on: anxiety (P = 0.007), emotional well-being (P = 0.01) and energy (P = 0.0002).

Women without menorrhagia had better outcomes with LNG-IUS than women with menorrhagia on EQ-5D (P = 0.03).

Women with menorrhagia had better outcomes with hysterectomy than LNG-OUS for: anxiety (P = 0.003), general health (P = 0.04), energy (P = 0.05), and pain relief (P = 0.04).
Funding source: Not stated

Study summary: Success or failure of treatment of menorrhagia is multi-factorial, so difficult to predict in individual cases.

From: Evidence Tables

Cover of Heavy Menstrual Bleeding
Heavy Menstrual Bleeding.
NICE Clinical Guidelines, No. 44.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2007 Jan.
Copyright © 2007, National Collaborating Centre for Women's and Children's Health.

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