Table A.5Cost data for pharmaceutical treatments used in the model

ParameterCost (£)Range (£)Source
COC pill
Initial GP consultation (10 minutes)24.00PSSRU
3 month follow-up GP consultation (10 minutes)24.00PSSRU
Routine annual follow-up GP consultation (10 minutes)24.00PSSRU
Cost per model cycle of COC pill (levonorgestrel 150 micrograms, ethinylestradiol 30 micrograms)a8.317.44–9.18BNF
Initial stage cost56.3155.44–57.18Includes cost of initial GP consultation, 3 month follow-up consultation and cost of treatment
Incremental stage cost14.3113.44–15.18Includes cost of drug and ¼ cost of follow-up appointment
Cost of discontinuation24.00Includes the cost of a GP consultation
LNG-IUS
Cost of device83.16BNF
Initial consultation and fitting:Costs: PSSRU
 GP (30 minutes)72.00Length: GDG opinion/LARC
 practice nurse (10 minutes)4.30
Sterile pack for insertion18.20LARC
4–6 week follow-up consultation:Costs: PSSRU
 GP (10 minutes)24.00Length: GDG opinion/LARC
 practice nurse (10 minutes)4.30
3 month follow-up GP consultation 10 minutes)24.00Costs: PSSRU
Length: GDG opinion/LARC
Consultation for removal:Costs: PSSRU
 GP (10 minutes)24.00Length: CDC opinion/LARC
 practice nurse (10 minutes)4.30
Routine annual follow-up GP consultation (10 minutes)24.00PSSRU
Sterile pack for removal3.17LARC
Initial stage cost229.66206.69–252.63Includes cost of initial GP consultation, 3 month follow-up consultation and cost of treatment
Incremental stage cost6.00Includes ¼ cost of annual follow-up appointment
Cost of discontinuation31.47Includes the cost of a GP consultation for removal and sterile removal pack
Tranexamic acid
Initial GP consultation (10 minutes)24.00PSSRU
3 month follow-up GP consultation (10 minutes)24.00PSSRU
Cost per model cycle of tranexamic acid (based on 28 pills per cycle)20.1617.28–23.04BNF; base case reflects median drug cost
Routine annual follow-up GP consultation (10 minutes)24.00PSSRU
Initial stage cost68.1665.28–71.04Includes cost of initial GP consultation, 3 month follow-up consultation and cost of treatment
Incremental stage cost26.1623.28–29.04Includes cost of drug and ¼ cost of follow-up appointment
Cost of discontinuation24.00Includes the cost of a GP consultation
NSAIDs (mefenamic acid)
Initial GP consultation (10 minutes)24.00PSSRU
3 month follow-up GP consultation (10 minutes)24.00PSSRU
Cost per model cycle of mefenamic acid (based on 45 pills per model cycle) – 500 mg, 21 tablet pack = £2.214.74BNF 50
Routine annual follow-up GP consultation (10 minutes)24.00PSSRU
Initial stage cost52.7447.47–58.01Includes cost of initial GP consultation, 3 month follow-up consultation and cost of treatment
Incremental stage cost10.749.67–11.81Includes cost of drug and ¼ cost of follow-up appointment
Cost of discontinuation24.00Includes the cost of a GP consultation

BNF = British National Formulary 50 (September 2005); COC = combined oral contraceptive; LARC = Long-acting Reversible Contraception guideline (NICE);286 PSSRU = Unit Costs of Health and Social Care (Personal Social Services Research Unit) 2005

a

This particular combination was chosen because RCT evidence is available for its effectiveness in treating menorrhagia. Sensitivity analysis on this cost reflects the cost of different options for this formulation.

From: Appendix A, Health economics

Cover of Heavy Menstrual Bleeding
Heavy Menstrual Bleeding.
NICE Clinical Guidelines, No. 44.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2007 Jan.
Copyright © 2007, National Collaborating Centre for Women's and Children's Health.

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