Low frequency repetitive transcranial magnetic stimulation (rTMS) vs control

DescriptionStatementStatements and Statistics
the severity of PTSD symptoms at 14 day follow up ( CAPS)s4The evidence is inconclusive and so it is not possible to determine if there is a clinically important difference between low frequency repetitive transcranial magnetic stimulation (rTMS) and control on reducing the severity of PTSD symptoms as measured by clinician-rated CAPS at 14 day follow up (k = 1; n = 14; SMD = 0.12; 95% CI, −0.94 to 1.18). I
the severity of post-treatment PTSD symptoms (PTSD checklist)s2yThere is limited evidence favouring control over low frequency repetitive transcranial magnetic stimulation (rTMS) on reducing the severity of post- treatment PTSD symptoms as measured by self-report PTSD (k = 1; n = 16; SMD = 0.82; 95% CI, −0.25 to 1.88). I
the severity of PTSD symptoms at 14 day follow up (PTSD checklist)s2yThere is limited evidence favouring control over low frequency repetitive transcranial magnetic stimulation (rTMS) on reducing the severity of PTSD symptoms at 14 day follow up as measured by self-report PTSD checklist (k = 1; n = 14; SMD = 0.67; 95% CI, −0.43 to 1.77). I
post treatment depression symptoms (Hamilton)S4The evidence is inconclusive and so it is not possible to determine if there is a clinically important difference between low frequency repetitive transcranial magnetic stimulation (rTMS) and control on reducing post treatment depression symptoms as measured by the clinician-rated Hamilton scale (k = 1; n = 14; SMD = −0.09; 95% CI, −1.15 to 0.97). I
Depression symptoms at 14 day follow up (Hamilton)s4The evidence is inconclusive and so it is not possible to determine if there is a clinically important difference between low frequency repetitive transcranial magnetic stimulation (rTMS) and control on reducing depression symptoms at 14 day follow up as measured by the clinician-rated Hamilton scale (k = 1; n = 14; SMD = 0.36; 95% CI, −0.71 to 1.43). I
post treatment anxiety (Hamilton)s4The evidence is inconclusive and so it is not possible to determine if there is a clinically important difference between low frequency repetitive transcranial magnetic stimulation (rTMS) and control on reducing post treatment anxiety symptoms as measured by the clinician-rated Hamilton Anxiety Rating Scale (k = 1; n = 14; SMD = 0.15; 95% CI, −0.91 to 1.21). I
anxiety symptoms at 14 day follow up (Hamilton)s2yThere is limited evidence favouring control over low frequency repetitive transcranial magnetic stimulation (rTMS) on reducing anxiety symptoms at 14 day follow up as measured by the clinician-rated Hamilton Anxiety Rating Scale (k = 1; n = 14; SMD = 0.57; 95% CI, −0.52 to 1.66). I
leaving the study prior to 14 day follow ups2xThere is limited evidence favouring low frequency repetitive transcranial magnetic stimulation (rTMS) over control on reducing the likelihood of leaving the study early due to any reason prior to 14 day follow up (k = 1; n = 18; RR = 0.8; 95% CI, 0.14 to 4.49). I

From: Appendix 16, Evidence statements

Cover of Post-Traumatic Stress Disorder
Post-Traumatic Stress Disorder: The Management of PTSD in Adults and Children in Primary and Secondary Care.
NICE Clinical Guidelines, No. 26.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): Gaskell; 2005.
Copyright © 2005, The Royal College of Psychiatrists & The British Psychological Society.

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