Adjunctive olanzapine (to SSRI) vs placebo

DescriptionStatementStatements and Statistics
Severity of PTSD symptoms mean endpoint scoress2xThere is limited evidence favouring adjunctive olanzapine (to SSRI) over placebo on reducing the severity of PTSD symptoms (Structured Interview for PTSD & CAPS - clinician) (k = 1; n = 19; SMD = −0.92; 95% CI, −1.88 to 0.04). I
Depression mean endpoint scoress2xThere is limited evidence favouring adjunctive olanzapine (to SSRI) over placebo on reducing depression (Center for Epidemiologic Studies Depression Scale - self-report) (k = 1; n = 19; SMD = −1.2; 95% CI, −2.2 to −0.21). I

From: Appendix 16, Evidence statements

Cover of Post-Traumatic Stress Disorder
Post-Traumatic Stress Disorder: The Management of PTSD in Adults and Children in Primary and Secondary Care.
NICE Clinical Guidelines, No. 26.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): Gaskell; 2005.
Copyright © 2005, The Royal College of Psychiatrists & The British Psychological Society.

All rights reserved. No part of this book may be reprinted or reproduced or utilised in any form or by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying and recording, or in any information storage or retrieval system, without permission in writing from the publishers. Enquiries in this regard should be directed to the Royal College of Psychiatrists.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.