Venlafaxine vs sertraline

DescriptionStatementStatements and Statistics
Severity of PTSD symptoms mean endpoint scoress3There is evidence suggesting there is unlikely to be a clinically important difference between venlafaxine and sertraline on reducing the severity of PTSD symptoms (CAPS - clinician) (k = 1; n = 352; SMD = −0.01; 95% CI, −0.22 to 0.2). I
Severity of PTSD symptoms mean endpoint scoress3There is evidence suggesting there is unlikely to be a clinically important difference between venlafaxine and sertraline on reducing the severity of PTSD symptoms (DTS - self-report) (k = 1; n = 352; SMD = −0.1; 95% CI, −0.31 to 0.11). I
Quality of life mean endpoint scoress3There is evidence suggesting there is unlikely to be a clinically important difference between venlafaxine and sertraline on improving quality of life (Q- LES-Q - self-report) (k = 1; n = 352; SMD = −0.02; 95% CI, −0.23 to 0.19). I
Quality of life mean endpoint scoress3There is evidence suggesting there is unlikely to be a clinically important difference between venlafaxine and sertraline on improving quality of life (Global Assessment of Functioning - clinician) (k = 1; n = 352; SMD = −0.01; 95% CI, −0.22 to 0.2). I
Likelihood of leaving treatment earlys4The evidence is inconclusive and so it is not possible to determine if there is a clinically important difference between venlafaxine and sertraline on reducing the likelihood of leaving treatment early (k = 1; n = 352; RR = 0.84; 95% CI, 0.62 to 1.14). I
Post-treatment PTSD diagnosiss4The evidence is inconclusive and so it is not possible to determine if there is a clinically important difference between venlafaxine and sertraline on reducing the likelihood of having a post-treatment PTSD diagnosis (k = 1; n = 352; RR = 0.92; 95% CI, 0.81 to 1.05). I

From: Appendix 16, Evidence statements

Cover of Post-Traumatic Stress Disorder
Post-Traumatic Stress Disorder: The Management of PTSD in Adults and Children in Primary and Secondary Care.
NICE Clinical Guidelines, No. 26.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): Gaskell; 2005.
Copyright © 2005, The Royal College of Psychiatrists & The British Psychological Society.

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